FITC标记的ADP核糖基化因子GTP酶激活蛋白1抗体
产品名称： FITC标记的ADP核糖基化因子GTP酶激活蛋白1抗体
英文名称： Anti-ARFGAP3/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ARFGAP3/FITC Conjugated antibody
FITC标记的ADP核糖基化因子GTP酶激活蛋白1抗体
| 英文名称 | Anti-ARFGAP3/FITC |
| 中文名称 | FITC标记的ADP核糖基化因子GTP酶激活蛋白1抗体 |
| 别 名 | ADP ribosylation factor GTPase activating protein 1; ADP ribosylation factor GTPase activating protein 3; ADP-ribosylation factor GTPase-activating protein 3; ARF GAP 3; ARFG3_HUMAN; ArfGAP 3; ARFGAP1; ARFGAP3; FLJ45618. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转运蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ARFGAP3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), ARFGAP2 (ADP-ribosylation factor GTPase-activating protein 2) and ARFGAP3 (ADP-ribosylation factor GTPase-activating protein 3) are GTPase-activating proteins (GAP) that are associated with the Golgi apparatus and interact with ADP-ribosylation factor 1 (ARF). These proteins promote hydrolysis of ARF-bound GTP and are required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of ARFGAP1, ARFGAP2 and ARFGAP3 is stimulated by phosphoinosides and inhibited by phosphatidylcholine. The genes encoding ARFGAP1, ARFGAP2 and ARFGAP3 map to human chromosomes 20q13.33, 11p11.2 and 22q13.2, respectively. Function: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. Subcellular Location: Cytoplasm. Golgi apparatus membrane. Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment. Tissue Specificity: Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary. Similarity: Contains 1 Arf-GAP domain. Database links: UniProtKB/Swiss-Prot: Q9NP61.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ARFGAP1(ADP-核糖基化因子GTPase激活蛋白1)、ARFGAP2(ADP-核糖基化因子GTPase激活蛋白2)和ARFGAP3(ADP-核糖基化因子GTPase激活蛋白3)是与高尔基体相关并与ADP-核糖体相互作用的GTPase激活蛋白(GAP)。转录因子1（ARF）。这些蛋白促进ARF结合的GTP的水解，并且从高尔基体衍生的膜和囊泡中解离外壳蛋白是必需的。这些囊泡与靶室的融合需要分离的外壳蛋白。磷酸肌苷刺激AGFGAP1、ARFGAP2和ARFGAP3的活性，并抑制磷脂酰胆碱的活性。AGFGAP1、ARFGAP2和ARFGAP3基因分别编码于人类染色体20q1333、11p11.2和22q132。