KCNJ1 polyclonal antibody
产品名称： KCNJ1 polyclonal antibody
英文名称： KCNJ1 polyclonal antibody
产品编号： PAB15638
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised aganist synthetic peptide of KCNJ1.
- Immunogen:
- A synthetic peptide corresponding to amino acids at internal region of human KCNJ1.
- Sequence:
- C-DQININFVVDAGNEN
- Host:
- Goat
- Theoretical MW (kDa):
- 44.8, 42.7
- Reactivity:
- Human
- Specificity:
- Approximately 45 KDa band observed in human, mouse and rat kidney lysates (calculated MW of 44.8 KDa according to NP_000211.1).
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Rare independent mutations in renal salt handling genes contribute to blood pressure variation.
Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, Newton-Cheh C, State MW, Levy D, Lifton RP.Nat Genet. 2008 May;40(5):592-9. Epub 2008 Apr 6.
- Entrez GeneID:
- 3758
- Protein Accession#:
- NP_000211.1
- Gene Name:
- KCNJ1
- Gene Alias:
- KIR1.1,ROMK,ROMK1
- Gene Description:
- potassium inwardly-rectifying channel, subfamily J, member 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- ATP-regulated potassium channel ROM-K,ATP-sensitive inward rectifier potassium channel 1,OTTHUMP00000045938,inwardly rectifying K+ channel,potassium inwardly-rectifying channel J1