FITC标记的神经元突触膜胞外分泌调节蛋白3抗体
产品名称： FITC标记的神经元突触膜胞外分泌调节蛋白3抗体
英文名称： Anti-RIMS3/FITC
产品编号： HZ-11359R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RIMS3/FITC Conjugated antibody
FITC标记的神经元突触膜胞外分泌调节蛋白3抗体
| 产品编号 | bs-11359R-FITC |
| 英文名称 | Anti-RIMS3/FITC |
| 中文名称 | FITC标记的神经元突触膜胞外分泌调节蛋白3抗体 |
| 别 名 | NIM 3; NIM3; Rab 3 interacting molecule 3; Regulating synaptic membrane exocytosis 3; Regulating synaptic membrane exocytosis protein 3; RIMS 3; RIMS-3; RIM 3; RIM3; RIM3 gamma; RIMS3; RIMS3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Zebrafish, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RIMS3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Rab 3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis and functions in an inhibitory capacity, controlling the recruitment and pooling of secretory vesicles at the plasma membrane. The Rim (Rab 3 interacting molecule) family of proteins (Rim1, Rim2, Rim3 and Rim4) are multidomain adaptors that regulate Rab 3 activity and sub-sequent neurotransmitter release. Rim3, also known as RIMS3 (regulating synaptic membrane exocytosis 3) or NIM3, is a 308 amino acid member of the Rim family. Localized to the synapse and to cell junctions, Rim3 contains one C2 domain and is thought to play an important role in the regulation of synaptic membrane exocytosis. Rim3, a protein that may be phosphorylated upon DNA damage, is expressed throughout the body with highest levels present in brain tissue. Function: RIMS3 belongs to a family of synaptic proteins that are essential for normal neurotransmitter release. It localizes primarily to neuronal dendrites and the postsynaptic densities, indicating that it may contribute to synapse transmission and plasticity. Subunit: Binds PPFIA3 (By similarity). Does not bind RAB3. Subcellular Location: Cell junction, synapse. Similarity: Contains 1 C2 domain. Database links: UniProtKB/Swiss-Prot: Q9UJD0.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
RAB 3，Rab家族的神经/神经内分泌特异性成员，参与Ca2+调节的胞吐作用和抑制能力的功能，控制在质膜上的分泌泡的募集和汇集。RIM（RaB 3相互作用分子）家族蛋白（RIM1、RIM2、RIM3和RIM4）是调节RAB 3活性和亚序神经递质释放的多域适配器。RIM3，也称为RIMS3（调节突触膜胞吐作用3）或NIM3，是RIM家族的308氨基酸成员。定位于突触和细胞连接，RIM3包含一个C2结构域，并被认为在调节突触膜胞吐作用中发挥重要作用。RIM3是一种在DNA损伤时可被磷酸化的蛋白质，在全身中表达，脑组织中存在最高水平。