FITC标记的磷酸化B淋巴细胞衔接分子DAPP1抗体
产品名称： FITC标记的磷酸化B淋巴细胞衔接分子DAPP1抗体
英文名称： Anti-phospho-DAPP1 (Tyr139)/FITC
产品编号： HZ-12983R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-20
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Rabbit Anti-phospho-DAPP1 (Tyr139)/FITC Conjugated antibody
FITC标记的磷酸化B淋巴细胞衔接分子DAPP1抗体
| 英文名称 | Anti-phospho-DAPP1 (Tyr139)/FITC |
| 中文名称 | FITC标记的磷酸化B淋巴细胞衔接分子DAPP1抗体 |
| 别 名 | DAPP1 (phospho Y139); p-DAPP1 (phospho Y139); B cell adapter molecule of 32 kDa; B lymphocyte adapter protein Bam32; B-cell adapter molecule of 32 kDa; BAM32; DAPP1; DAPP1_HUMAN; DKFZp667E0716; Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; Dual adaptor of phosphotyrosine and 3 phosphoinositides; hDAPP1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 心血管 细胞生物 神经生物学 淋巴细胞 b-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human DAPP1 around the phosphorylation site of Tyr139 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: B cell adapter molecule is also designated dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (DAPP1) or B lymphocyte adapter protein. BAM32 is a B cell-associated adapter that is crucial for B cell antigen receptor signaling regulation. BAM32 interacts with Ptdlns and PLC g2 and, upon B cell activation, the protein is phosphorylated on tyrosine residues. It is a mainly cytoplasmic protein that can translocate to the cell membrane after cell stimulation. BAM32, which contains one PH domain and one SH2 domain, is primarily expressed in placenta and lung tissues, but can also be detected in heart, liver, pancreas and brain. Function: May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. Subcellular Location: Cytoplasm. Membrane. Membrane-associated after cell stimulation leading to its translocation. Tissue Specificity: Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells. Post-translational modifications: Phosphorylated on tyrosine residues. Similarity: Contains 1 PH domain. Contains 1 SH2 domain. Database links: UniProtKB/Swiss-Prot: Q9UN19.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
B细胞适配器分子也是指定的磷酸和磷酸肌醇3磷酸酪氨酸和双适配器（dapp1）或B淋巴细胞适配器蛋白。BAM32是B细胞相关的适配器，是B细胞抗原受体信号调节的关键。BAM32与PTDLNs和PLC G2相互作用，并且在B细胞活化时，蛋白质在酪氨酸残基上磷酸化。它是一种主要的细胞质蛋白，可在细胞刺激后转运到细胞膜上。B细胞抗原受体，其中包含一个PH结构域和一个SH2结构域，主要在胎盘和肺组织中表达，但也可以发现在心脏、肝脏、胰腺和大脑。