GSK3B (phospho S21/29) polyclonal antibody
产品名称: GSK3B (phospho S21/29) polyclonal antibody
英文名称: GSK3B (phospho S21/29) polyclonal antibody
产品编号: PAB0479
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of GSK3B.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S21/29 of human GSK3B.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Immunohistochemistry (1:50-100)
Western Blot (1:250-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells.
Wang L, Lin HK, Hu YC, Xie S, Yang L, Chang C.J Biol Chem. 2004 Jul 30;279(31):32444-52. Epub 2004 Jun 3.
- 2.
- 14-3-3 binds to and mediates phosphorylation of microtubule-associated tau protein by Ser9-phosphorylated glycogen synthase kinase 3beta in the brain.
Yuan Z, Agarwal-Mawal A, Paudel HK.J Biol Chem. 2004 Jun 18;279(25):26105-14. Epub 2004 Apr 8.
- 3.
- Glycogen synthase kinase-3beta activity is required for androgen-stimulated gene expression in prostate cancer.
Liao X, Thrasher JB, Holzbeierlein J, Stanley S, Li B.Endocrinology. 2004 Jun;145(6):2941-9. Epub 2004 Feb 26.
- Applications
- Western Blot (Tissue lysate)
- The GSK3B (phospho S21/29) polyclonal antibody (Cat # PAB0479) is used in Western blot to detect Phospho-GSK3B-S21/29 in mouse thymus tissue lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with GSK3B (phospho S21/29) polyclonal antibody (Cat # PAB0479) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 2932
- Protein Accession#:
- NP_002084;P49841
- Gene Name:
- GSK3B
- Gene Alias:
- -
- Gene Description:
- glycogen synthase kinase 3 beta
- Omim ID:
- 605004
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene
- Other Designations:
- GSK3beta isoform,glycogen synthase kinase-3 beta
- Interactome
- Gene Pathway
- Alzheimer's disease
- Axon guidance
- B cell receptor signaling pathway
- Basal cell carcinoma
- Cell cycle
- Chemokine signaling pathway
- Colorectal cancer
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Hedgehog signaling pathway
- Insulin signaling pathway
- Melanogenesis
- Neurotrophin signaling pathway
- Pathways in cancer
- Prostate cancer
- T cell receptor signaling pathway
- Wnt signaling pathway
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Amphetamine-Related Disorders
- Anorexia Nervosa
- Bipolar Disorder
- Bone Diseases
- Breast cancer
- Breast Neoplasms
- Bulimia
- Cardiovascular Diseases
- Cognition
- Dementia
- Depressive Disorder
- Depressive Disorder, Major
- Diabetes Mellitus, Type 2
- Disease Models, Animal
- Disease Progression
- Drug Toxicity