Semaphorin 3E,轴突导向因子SEMA3E抗体

产品编号HZ-11480R
英文名称Semaphorin 3E
中文名称轴突导向因子SEMA3E抗体
别 名Coll 5; Coll5; KIAA0331; M sema H; M SEMAH; M SemaK; Msema H; MSEMAH; MSemaK; SEM3E_HUMAN; Sema domain immunoglobulin domain (Ig); Sema domain immunoglobulin domain (Ig) short basic domain secreted 3E; Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; SEMA3E; SEMAH; Semaphorin 3E; Semaphorin-3E; Semaphorin3E; Short basic domain secreted (semaphorin) 3E; SEM3E_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
Semaphorin 3E,轴突导向因子SEMA3E抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量86kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SEMA3E/Semaphorin 3E (401-450aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Semaphorin 3E,轴突导向因子SEMA3E抗体PubMedPubMed
产品介绍background:
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

Function:
Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation

Subunit:
Interacts with PLXND1

Subcellular Location:
Secreted.

Similarity:
Belongs to the semaphorin family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Sema domain.

Semaphorin 3E,轴突导向因子SEMA3E抗体Database links:
Entrez Gene: 9723 Human
Entrez Gene: 20349 Mouse
Entrez Gene: 100524100 Pig
Entrez Gene: 296789 Rat
Entrez Gene: 535644 Cow
Entrez Gene: 483387 Dog
Omim: 608166 Human
SwissProt: O15041 Human
SwissProt: P70275 Mouse
SwissProt: Q9QX23 Mouse
Unigene: 528721 Human
Unigene: 134093 Mouse
Unigene: 214084 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.