JMJD7,组蛋白去甲基转移酶JMJD7抗体

产品编号HZ-9486R
英文名称JMJD7
中文名称组蛋白去甲基转移酶JMJD7抗体
别 名JmjC domain-containing protein 7; JMJD7; JMJD7_HUMAN; Jumonji domain containing 7; Jumonji domain-containing protein 7.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
JMJD7,组蛋白去甲基转移酶JMJD7抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量36kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human JMJD7
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
JMJD7,组蛋白去甲基转移酶JMJD7抗体PubMedPubMed
产品介绍background:
A crucial regulator of chromatin dynamics and DNA transcription is the covalent modification and methylation of histones. Generally, methylation of certain lysine residues on Histone H3 and Histone H4 can be associated with transcriptionally active or inactive chromatin. This regulation has profound effects on the expression of genes and is part of an epigenetic memory network that determines cell fate. JMJD7 (Jumonji domain-containing protein 7) is a member of a family of JMJC domain-containing histone demethylases that are directly involved in removing methyl residues from distinct and unique lysine residues. These actions are implicated in gene expression and the regulation of cell senescence. JMJC domain-containing histone demethylases are also likely involved in development via their ability to regulate gene expression. JMJD7 contains one JMJC domain and was originally thought to be an alternatively spliced isoform of PLA2G4B.

Similarity:
Contains 1 JmjC domain.

Database links:
Entrez Gene: 100137047 Human
Entrez Gene: 433466 Mouse
Entrez Gene: 100137086 Rat
SwissProt: P0C870 Human
SwissProt: P0C872 Mouse
Unigene: 198161 Human
Unigene: 482417 Mouse

JMJD7,组蛋白去甲基转移酶JMJD7抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.