STK11 (phospho S334) polyclonal antibody
产品名称： STK11 (phospho S334) polyclonal antibody
英文名称： STK11 (phospho S334) polyclonal antibody
产品编号： PAB8094
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of STK11.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S334 of human STK11.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- An efficient expression system for the production of functionally active human LKB1.
Martinez-Torrecuadrada JL, Romero S, Nunez A, Alfonso P, Sanchez-Cespedes M, Casal JI.J Biotechnol. 2005 Jan 12;115(1):23-34.
- 2.
- IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.
Suzuki A, Kusakai G, Kishimoto A, Shimojo Y, Ogura T, Lavin MF, Esumi H.Biochem Biophys Res Commun. 2004 Nov 19;324(3):986-92.
- 3.
- The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. Epub 2004 Feb 25.
- Entrez GeneID:
- 6794
- Protein Accession#:
- NP_000446;Q15831
- Gene Name:
- STK11
- Gene Alias:
- LKB1,PJS
- Gene Description:
- serine/threonine kinase 11
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq
- Other Designations:
- polarization-related protein LKB1,serine/threonine protein kinase 11
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Large Cell
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Colonic Neoplasms
- Colonic Polyps
- Diabetes Complications
- Diabetes Mellitus
- Diabetes Mellitus, Type 2
- Gastrointestinal Neoplasms
- Genetic Predisposition to Disease
- Hyperandrogenism
- Hyperinsulinism