Cdc7,细胞分裂周期蛋白7抗体

产品编号bs-5148R
英文名称Cdc7
中文名称细胞分裂周期蛋白7抗体
别 名Cdc 7; Cdc-7; Cdc7; CDC7 cell division cycle 7; CDC7 cell division cycle 7 like 1; CDC7 L1; Cdc7 like 1; CDC7 related kinase; CDC7L 1; CDC7L1; Cell division cycle 7 homolog; Cell division cycle 7 kinase; Cell division cycle 7 like protein 1; Cell division cycle 7 related protein kinase; HsCDC 7; HsCDC7; Hsk 1; Hsk1; HuCDC 7; CDC7_HUMAN.
说 明 书0.1ml 0.2ml
研究领域免疫学 信号转导 细胞周期蛋白 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse,
Cdc7,细胞分裂周期蛋白7抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:30-300 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量64kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Cdc7
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Cdc7,细胞分裂周期蛋白7抗体PubMedPubMed
产品介绍background:
DNA replication in eukaryotic cells is dependent on the phosphorylation of the pre-replicative complex (preRC) at the origin of replication. Two complexes of proteins mediate this event, the cyclin dependent kinase (CDK) complex, and the Cdc7 kinase-ASK complex. The activity of Cdc7 kinase oscillates during cell cycle. The major targets of Cdc7 kinase are proteins that belong to the MCM complex (mini chromosome maintenance proteins). Cdc7 kinase was also found to be important in meiosis, checkpoint responses, maintenance of chromosome structure, and repair.

Function:
Seems to phosphorylate critical substrates that regulatethe G1/S phase transition and/or DNA replication. Canphosphorylates MCM2 and MCM3.

Subunit:
Forms a complex with either DBF4/DBF4A or DBF4B, leadingto the activation of the kinase activity.

Subcellular Location:
Nucleus.

Similarity:
elongs to the protein kinase superfamily. Ser/Thrprotein kinase family. CDC7 subfamily.
Contains 1 protein kinase domain.

Gene ID:
8317

Cdc7,细胞分裂周期蛋白7抗体Database links:
Entrez Gene: 8317 Human
Omim: 603311 Human
SwissProt: O00311 Human
Unigene: 533573 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.