AXIN2 (Human) Recombinant Protein (P01)
产品名称： AXIN2 (Human) Recombinant Protein (P01)
英文名称： AXIN2 (Human) Recombinant Protein (P01)
产品编号： H00008313-P01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human AXIN2 full-length ORF ( AAH06295.1, 1 a.a. - 160 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVANDFCHDILFYLYCKLCIIKSSFKENYLVQ
- Theoretical MW (kDa):
- 44.4
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 8313
- GeneBank Accession#:
- BC006295.2
- Protein Accession#:
- AAH06295.1
- Gene Name:
- AXIN2
- Gene Alias:
- AXIL,DKFZp781B0869,MGC10366,MGC126582
- Gene Description:
- axin 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq
- Other Designations:
- conductin
- Related Disease
- Adenocarcinoma
- Breast cancer
- Breast Neoplasms
- Carcinoma, Squamous Cell
- Cleft Lip
- Cleft Palate
- Colorectal Neoplasms
- Dental Enamel Hypoplasia
- Depressive Disorder, Major
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Hirschsprung Disease
- Lung Neoplasms
- Neoplasm Invasiveness
- Neoplasms, Second Primary
- Osteoporosis, Postmenopausal
- Ovarian cancer
- Ovarian Neoplasms