FITC标记的γ-衔接蛋白相关蛋白3抗体-抗体-抗体-生物在线
上海沪震实业有限公司
FITC标记的γ-衔接蛋白相关蛋白3抗体

FITC标记的γ-衔接蛋白相关蛋白3抗体

商家询价

产品名称： FITC标记的γ-衔接蛋白相关蛋白3抗体

英文名称： Anti-GGA3/FITC

产品编号： HZ-13345R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-GGA3/FITC Conjugated antibody

FITC标记的γ-衔接蛋白相关蛋白3抗体

 

英文名称 Anti-GGA3/FITC
中文名称 FITC标记的γ-衔接蛋白相关蛋白3抗体
别    名 ADP ribosylation factor binding protein 3; ADP ribosylation factor binding protein GGA 3; ADP ribosylation factor binding protein GGA3; ADP-ribosylation factor-binding protein GGA3; ARF binding protein GGA 3; ARF binding protein GGA3; ARF-binding protein 3; gamma ear-containing; GGA 3; GGA3; GGA3_HUMAN; Golgi associated gamma adaptin ear containing ARF binding protein 3; Golgi localized gamma ear containing ARF binding protein 3; Golgi-localized; KIAA0154.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  转运蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 78kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GGA3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The GGA family of proteins (Golgi-localized, g-Adaptin ear-containing, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin. Members of the GGA family, GGA1,GGA2 (also known as VEAR) and GGA3, are multi-domain proteins that bind mannose 6-phosphate receptors (MPRs). GGAs have modular structures with an N-terminal VHS (VPS27, Hrs and STAM) domain followed by a GAT (GGA and Tom1) domain, a connecting hinge segment and a C-terminal GAE (g-Adaptin ear) domain. The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences. The human GGA3 gene maps to chromosome 17 and encodes a 723 amino acid protein that shares 46% sequence identity with GGA1 and 38% with GGA2.

Function:
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

Subunit:
Monomer. Interacts with SORT1, SORL1, LRP3, GGA binding partner (GGABP) and P200 (By similarity). Interacts with GGA1 and GGA2. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the membrane proteins M6PR/CD-MPR, IGF2R/CI-MPR and BACE1 and the accessory proteins SYNRG, EPN4, NECAP1, NECAP2 and AFTPH/aftiphilin. Interacts with TSG101 and UBC. 

Subcellular Location:
Golgi apparatus; trans-Golgi network membrane. Endosome membrane.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Phosphorylated by CK2 and dephosphorylated by PP2A (By similarity). Phosphorylation of GGA3 allows the internal AC-LL motif to bind the VHS domain and to inhibit the recognition of cargo signals.
Ubiquitinated.

Similarity:
Belongs to the GGA protein family.
Contains 1 GAE domain.
Contains 1 GAT domain.
Contains 1 VHS domain.

Database links:
UniProtKB/Swiss-Prot: Q9NZ52.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
   

GGA蛋白家族(Golgi定位，g-Adaptin含耳，ARF结合蛋白)是普遍存在的外壳蛋白，通过与TGN分选受体ARF(ADP-ribos)相互作用，促进可溶性蛋白从反式Golgi网络(TGN)向内体/溶酶体的运输。酰化因子）和网格蛋白。GGA家族的成员GGA1，GGA2（也称为VEAR）和GGA3，是结合甘露糖6-磷酸受体（MPR）的多结构域蛋白。GGA具有模块化结构，具有N端VHS(VPS27，Hrs和STAM)域，接着是GAT(GGA和Tom1)域、连接铰链段和C端GAE(g-Adaptin ear)域。GGA的氨基末端VHS结构域通过识别酸性簇二亮氨酸（ACLL）序列与受体的分类胞浆结构域形成复合物。人类GGA3基因定位于染色体17，编码一个723个氨基酸的蛋白质，与GGA1共有46%的序列同一性，与GGA2共有38%的序列同一性。