MSR1 monoclonal antibody, clone SRA-E5
产品名称： MSR1 monoclonal antibody, clone SRA-E5
英文名称： MSR1 monoclonal antibody, clone SRA-E5
产品编号： MAB1710
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant MSR1.
- Immunogen:
- Recombinant protein corresponding to human MSR1.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (0.1% proclin, 2.0% Block Ace)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
- Recommend Usage:
- Immunohistochemistry (10 ug/mL)
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Production, characterization, and interspecies reactivities of monoclonal antibodies against human class A macrophage scavenger receptors.
Tomokiyo R, Jinnouchi K, Honda M, Wada Y, Hanada N, Hiraoka T, Suzuki H, Kodama T, Takahashi K, Takeya M.Atherosclerosis. 2002 Mar;161(1):123-32.
- Entrez GeneID:
- 4481
- Gene Name:
- MSR1
- Gene Alias:
- CD204,SCARA1,SR-A,phSR1,phSR2
- Gene Description:
- macrophage scavenger receptor 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq
- Other Designations:
- OTTHUMP00000120049,OTTHUMP00000120050,macrophage acetylated LDL receptor I and II,macrophage scavenger receptor type III,scavenger receptor class A, member 1
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Atherosclerosis
- Atherosclerosis
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Coronary Artery Disease
- Coronary Disease
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Disease Susceptibility
- Edema
- Genetic Predisposition to Disease
- Inflammation
- Lung Neoplasms
- Metabolic Syndrome X
- Neoplasm Metastasis
- Neoplasms