CPNE1,钙依赖膜结合蛋白Copine蛋白1抗体

产品编号HZ-14024R
英文名称CPNE1
中文名称钙依赖膜结合蛋白Copine蛋白1抗体
别 名Copine 1; Copine I; Copine-1; Copine1; CopineI; COPN 1; COPN1; CPN 1; CPN1; CPNE 1; CPNE1; CPNE1_HUMAN; MGC1142.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 信号转导 转运蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Sheep,
CPNE1,钙依赖膜结合蛋白Copine蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量59kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CPNE1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CPNE1,钙依赖膜结合蛋白Copine蛋白1抗体PubMedPubMed
产品介绍background:
Copine I is a member of the copine family of evolutionarily conserved, soluble, calcium-dependent, membrane-binding proteins. Members of the copine family are involved in signal transduction and membrane trafficking. Copine I is ubiquitously expressed and contains two N-terminal C2 domains and one C-terminal VWFA (von Willebrand factor A) domain, which is also referred to as the A domain or the core domain. As is characteristic of the copine family, copine I functions in membrane trafficking and is capable of binding phospholipids in a calcium-dependent manner. Copine I is also able to bind liposomes. Via its VWFA domain, copine I directly interacts with the ubiquitin-conjugating enzyme, UBC12, and may play a role in the regulation of TNF alpha-signaling.

Function:
May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties.

Subunit:
Interacts with CCDC22.

Subcellular Location:

DISEASE:

Similarity:
Belongs to the copine family.
Contains 2 C2 domains.
Contains 1 VWFA domain.

Gene ID:
615677

Database links:
Entrez Gene: 615677 Cow
Entrez Gene: 477213 Dog
Entrez Gene: 8904 Human
Entrez Gene: 266692 Mouse
Entrez Gene: 100233174 Pig
Entrez Gene: 100328904 Rabbit
Omim: 604205 Human
SwissProt: Q99829 Human
SwissProt: Q8C166 Mouse
Unigene: 246413 Human
Unigene: 700188 Human
Unigene: 27660 Mouse

CPNE1,钙依赖膜结合蛋白Copine蛋白1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.