TACI,肿瘤坏死因子受体超家族成员13B抗体

产品编号HZ-4841R
英文名称TACI
中文名称肿瘤坏死因子受体超家族成员13B抗体
别 名TACI; CD267; CD267 antigen; CVID; TNFRSF 13B; TNFRSF 14B;TNFRSF13B; TNFRSF13B protein; TNFRSF14B; Transmembrane activator and CAML interactor; Tumor necrosis factor receptor 13B; Tumor necrosis factor receptor superfamily member 13B.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 淋巴细胞 t-淋巴细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
TACI,肿瘤坏死因子受体超家族成员13B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量32kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human TNFRSF13B/CD267/TACI
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
TACI,肿瘤坏死因子受体超家族成员13B抗体PubMedPubMed
产品介绍background:
TACI is a lymphocyte specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein binds to both APRIL and BAFF and induces activation of the transcription factors NFAT (nuclear-factor of activated T cells), AP1, and NF kappa B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith Magenis syndrome region on chromosome 17.

Subcellular Location:
Membrane; Single-pass type III membrane protein.

Tissue Specificity:
Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells.

Similarity:
Contains 2 TNFR-Cys repeats.

Database links:
Entrez Gene: 23495 Human
Entrez Gene: 57916 Mouse
Omim: 604907 Human
SwissProt: O14836 Human
SwissProt: Q9ET35 Mouse
Unigene: 158341 Human
Unigene: 265915 Mouse

TACI,肿瘤坏死因子受体超家族成员13B抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.