FITC标记的粘蛋白-1抗体
产品名称： FITC标记的粘蛋白-1抗体
英文名称： Anti-CA153/FITC
产品编号： HZ-4763R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200
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Rabbit Anti-CA153/FITC Conjugated antibody
FITC标记的粘蛋白-1抗体
| 产品编号 | bs-4763R-FITC |
| 英文名称 | Anti-CA153/FITC |
| 中文名称 | FITC标记的粘蛋白-1抗体 |
| 别 名 | Breast carcinoma associated antigen DF3; Breast carcinoma associated antigen DF3; Breast carcinoma-associated antigen DF3; CA 15 3; CA 15-3; CA15 3; CA15 3 antigen; CA15.3; Cancer antigen 15-3; Carcinoma associated mucin; Carcinoma associated mucin; Carcinoma-associated mucin; CD 227; CD227; CD227; CD227 antigen; DF3 antigen; DF3 antigen; EMA; EMA; Episialin; Episialin; Epithelial membrane antigen; Epithelial membrane antigen; Epithelial mucin tandem repeat sequence; H23 antigen; H23 antigen; H23AG; H23AG; HGNC:7508; KL 6; KL-6; KL6; Krebs von den Lungen-6; MAM 6; MAM6; MUC 1; MUC 1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1; MUC1-alpha; MUC1-beta; MUC1-CT; MUC1-NT; MUC1/ZD; MUC1_HUMAN; Mucin 1; Mucin 1 precursor; Mucin 1 transmembrane; Mucin-1 subunit beta; Mucin1; Mucin1; Peanut reactive urinary mucin; Peanut reactive urinary mucin; Peanut-reactive urinary mucin; PEM; PEMT; PEMT; Polymorphic epithelial mucin; Polymorphic epithelial mucin; PUM; PUM; Tumor associated epithelial membrane antigen; Tumor associated epithelial membrane antigen; Tumor associated epithelial mucin; Tumor associated mucin; Tumor associated mucin; Tumor-associated epithelial membrane antigen; Tumor-associated mucin. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 t-淋巴细胞 上皮细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | Flow-Cyt=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 138kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CA153/EMA/MUC1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Subunit: Contains 1 SEA domain. Subcellular Location: Secreted; Cell membrane. Cytoplasm. Nucleus. On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus and Apical cell membrane. Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions. Tissue Specificity: Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 is expressed in tumor cells only. Database links: Entrez Gene: 4582 Human Entrez Gene: 17829 Mouse Omim: 158340 Human SwissProt: P15941 Human SwissProt: Q02496 Mouse Unigene: 89603 Human Unigene: 16193 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CA153为高分子糖蛋白，是乳腺癌标志物之一，其表达的量与乳腺癌的分化程度及雌激素受体高低有关联。近年来，很多学者研究认为：在人的很多种恶性肿瘤中都有CA15-3的不同表达 |
MUC1是一种大的细胞表面粘蛋白糖蛋白，由大多数腺和导管上皮细胞和一些造血细胞谱系表达。它在大多数分泌上皮上表达，包括乳腺和一些造血细胞。它在乳腺泌乳中大量表达，在90%例乳腺癌和转移瘤中大量表达。转基因MUC1已被证明与所有四个CEBB受体和本地化的ERBB1（EGFR）在泌乳腺。MUC1基因包含七个外显子，并产生几种不同的交替剪接变异体。MUC1的主要表达形式使用所有七个外显子，并且是一种具有大的胞外串联重复结构域的1型跨膜蛋白。串联重复结构域是高度O糖基化和糖基化的改变已被显示在上皮癌细胞。