FITC标记的19号染色体开放阅读框29抗体
产品名称： FITC标记的19号染色体开放阅读框29抗体
英文名称： Anti-C19orf29/FITC
产品编号： HZ-9960R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-C19orf29/FITC Conjugated antibody
FITC标记的19号染色体开放阅读框29抗体
| 产品编号 | bs-9960R-FITC |
| 英文名称 | Anti-C19orf29/FITC |
| 中文名称 | FITC标记的19号染色体开放阅读框29抗体 |
| 别 名 | C19orf29; Cactin; CS029_HUMAN; FLJ17482; FLJ59622; fSAPc; Renal carcinoma antigen NY-REN-24; Uncharacterized protein C19orf29. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 89kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Cactin/C19orf29 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc?receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3. The C19orf29 gene product has been provisionally designated C19orf29 pending further characterization. Function: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing. Subunit: Interacts (via N-terminus domain) with NFKBIL1; the interaction occurs in a proinflammatory-independent manner. Does not interact with RELA NF-kappa-B subunit. Identified in the spliceosome C complex. Subcellular Location: Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus. Similarity: Belongs to the CACTIN family. Database links: Entrez Gene: 58509 Human SwissProt: Q8WUQ7 Human SwissProt: Q9CS00 Mouse Unigene: 727616 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由约6300万个碱基组成的1400个以上的基因，19号染色体构成了人类基因组DNA的2%以上。第19染色体包括多种有趣的基因，并被公认为具有人类染色体最大的基因密度。它是许多免疫球蛋白超家族成员的遗传家，包括杀伤细胞和白细胞Ig样受体，一些ICAMs，CEACAM和PSG家族，和Fc？受体。眼睛颜色和头发颜色的关键基因也映射到19号染色体上。Putz JeHHER综合征、脊髓小脑共济失调6型、卒中障碍CADASIL、高胆固醇血症和胰岛素依赖型糖尿病与19号染色体有关。19号染色体和14号染色体易位在某些淋巴增生性疾病中可见，并且通常涉及原癌基因BCL3。C19ORF29基因产物已暂时指定为C19OF29，有待进一步鉴定。