FBLIM1 抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
FBLIM1 抗体

FBLIM1 抗体

商家询价

产品名称： FBLIM1 抗体

英文名称： FBLIM1 Antibody

产品编号： XY13349-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 FBLIM1 抗体

Applications
In-house applications ELISA, WB, IHC     Application not tested? Please see our Guarantee.
Published applications IF Publications 1 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human
Images
Prev1NextView more validation data
  • 13349-1-AP;HepG2 cellsHepG2 cells were subjected to SDS PAGE followed by western blot with 13349-1-AP(FBLIM1 antibody) at dilution of 1:500
  • 13349-1-AP;human lung cancerImmunohistochemical of paraffin-embedded human lung cancer using 13349-1-AP(FBLIM1 antibody) at dilution of 1:100 (under 10x lens)
  • 13349-1-AP;human lung cancerImmunohistochemical of paraffin-embedded human lung cancer using 13349-1-AP(FBLIM1 antibody) at dilution of 1:100 (under 40x lens)
Positive WB detected in HepG2 cells, HEK-293 cells, HeLa cells, human heart tissue, K-562 cells
Positive IHC detected in Human lung cancer tissue
Recommended dilution WB : 1:500-1:5000
IHC : 1:20-1:200
 FBLIM1 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen FBLIM1 fusion protein ag3907 Full name Filamin binding LIM protein 1
Calculated molecular
weight		 373aa,41 kDa Observed molecular 
weight		 45-48 kDa
GenBank accession 
number		 BC019895 Gene ID (NCBI) 54751
Gene symbol FBLIM1 Synonyms CAL, DKFZp434G171, FBLIM1, FBLP 1, FBLP1, filamin binding LIM protein 1, MIG2 interacting protein, Migfilin, RP11 169K16.5
Background FBLIM1 抗体

FBLIM1, also known as CAL, Mig-2-interacting protein or Migfilin, is a cytoplasmic protein that belongs to the LIM superfamily. FBLIM1 is a protein found in cell-cell and cell-ECM connections where it co-localizes with FLNA/C and FLNB. FBLIM1 was found to bind directly to FLNA/C and to be an important regulator of cell shape and motility. FBLIM1 exerts its influence on cellular functions by interacting with various binding partners; FLN via its N- terminal domain, VASP and Src via its proline-rich region, and kindlin-2 and the cardiac transcription factor, CSX/NKX2-5 via its C-terminal LIM domains. Three isoforms exist for FBLIM1 due to alternative splicing events, namely FBLP-1A, FBLP-1 and FBLP-1B. FBLIM1 serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. It is associated with actin stress fiber at cell-ECM focal adhesion sites. FBLP-1A and FBLP-1B are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with PLEKHC1. FBLP-1 is localized at actin stress fibers. FBLIM1 is implicated in cell shape modulation (spreading) and motility. FBLIM1 participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. It may also regulate the assembly of filamin-containing signaling complexes that control actin assembly. In addition, FBLIM1 is capable of translocating to the nucleus and regulating gene expression. This antibody is a rabbit polyclonal antibody raised against full length human FBLIM1 antigen. FBLIM1 抗体

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