ITGA2B monoclonal antibody, clone MEM-06 (PE)
产品名称： ITGA2B monoclonal antibody, clone MEM-06 (PE)
英文名称： ITGA2B monoclonal antibody, clone MEM-06 (PE)
产品编号： MAB4431
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native ITGA2B.
- Immunogen:
- Native purified ITGA2B from leukocytes of a patient suffering from a LGL-type leukemia.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- This antibody reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 KDa) and GPIIb beta (light chain; 23 KDa). CD41 is mainly expressed on platelets and megakaryocytes.
- Form:
- Liquid
- Conjugation:
- PE
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (0.2% BSA, 15 mM sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation.
Zhang J, Varas F, Stadtfeld M, Heck S, Faust N, Graf T.Exp Hematol. 2007 Mar;35(3):490-499.
- 2.
- CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo.
Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC.Development. 2003 Sep;130(18):4393-403.
- 3.
- Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells.
Mitjavila-Garcia MT, Cailleret M, Godin I, Nogueira MM, Cohen-Solal K, Schiavon V, Lecluse Y, Le Pesteur F, Lagrue AH, Vainchenker W.Development. 2002 Apr;129(8):2003-13.
- Entrez GeneID:
- 3674
- Gene Name:
- ITGA2B
- Gene Alias:
- CD41,CD41B,GP2B,GPIIb,GTA,HPA3
- Gene Description:
- integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
- Other Designations:
- integrin alpha 2b,platelet fibrinogen receptor, alpha subunit,platelet-specific antigen BAK
- Related Disease
- Abortion, Spontaneous
- Acute Chest Syndrome
- Acute Disease
- Alzheimer Disease
- Alzheimer disease
- Anemia, Sickle Cell
- Anemia, sickle cell
- Angina, Unstable
- Antiphospholipid Syndrome
- Arterial Occlusive Diseases
- Arteriosclerosis
- Atherosclerosis
- Brain Ischemia
- Cardiovascular Diseases
- Carotid Stenosis
- Cerebrovascular Accident
- Cerebrovascular Disorders
- Coronary Artery Disease
- Coronary Disease