FITC标记的活化T细胞核因子胞浆相互作用蛋白2抗体
产品名称： FITC标记的活化T细胞核因子胞浆相互作用蛋白2抗体
英文名称： Anti-NFATC2IP/FITC
产品编号： HZ-19223R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NFATC2IP/FITC Conjugated antibody
FITC标记的活化T细胞核因子胞浆相互作用蛋白2抗体
| 英文名称 | Anti-NFATC2IP/FITC |
| 中文名称 | FITC标记的活化T细胞核因子胞浆相互作用蛋白2抗体 |
| 别 名 | 45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; cytoplasmic 2-interacting protein; ESC2; NF2IP_HUMAN; NFAT-interacting protein, 45-KD; NFATC2-interacting protein; Nfatc2ip; NIP45; Nuclear factor of activated T-cells; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein; RAD60. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Cynomolgus Monkey |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NFATC2IP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: NFATc2IP is a 419 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one ubiquitin-like domain. Interacting with NFATc2, TRAF1 and TRAF2, NFATc2IP plays a role in the inducible expression of cytokines in T-cells, specifically by enhancing NFATc2-induced interleukin (IL) production. NFATc2IP exists as three alternatively spliced isoforms and is subject to post-translational methylation; an event which augments NFATc2IP-regulated cytokine production. The gene encoding NFATc2IP maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially by increasing NFAT-driven IL-4 production. Subcellular Location: Nucleus. Cytoplasm. TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus. Post-translational modifications: Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production. Similarity: Contains 1 ubiquitin-like domain. Database links: Entrez Gene: 84901 Human Entrez Gene: 18020 Mouse Entrez Gene: 308983 Rat Omim: 614525 Human SwissProt: Q9GLZ9 Cynomolgus Monkey SwissProt: Q8NCF5 Human SwissProt: O09130 Mouse SwissProt: Q6AYG7 Rat Unigene: 513470 Human Unigene: 1389 Mouse Unigene: 101030 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NFATC2IP是一个419个氨基酸的蛋白质，定位于细胞核和细胞质中，并含有一个泛素样结构域。NFATc2IP与NFATc2、TRAF1、TRAF2相互作用，通过增强NFATc2诱导的白细胞介素（IL）的产生，在T细胞诱导表达细胞因子中发挥作用。NFATc2IP以三种可选择的剪接异构体存在，并受翻译后甲基化的影响；这一事件增强NFATc2IP调节的细胞因子产生。编码NFATC2IP的基因映射到人类16号染色体上，编码900个以上的基因并包含人类基因组的近3%。GAN基因位于16号染色体上，随着突变，可能导致巨大的轴突神经病变，一种神经系统紊乱，特征是随着生长而增加功能障碍。罕见的Rubinstein-Taybi综合征也与16号染色体有关，克罗恩病也是如此，克罗恩病是一种胃肠道炎症性疾病。