FITC标记的丝氨酸蛋白酶8抗体
产品名称： FITC标记的丝氨酸蛋白酶8抗体
英文名称： Anti-PRSS8/FITC
产品编号： HZ-6064R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-PRSS8/FITC Conjugated antibody
FITC标记的丝氨酸蛋白酶8抗体
| 英文名称 | Anti-PRSS8/FITC |
| 中文名称 | FITC标记的丝氨酸蛋白酶8抗体 |
| 别 名 | CAP1; Channel Activating Protease 1; mCAP1; Prostasin; Prostasin heavy chain; protease, serine, 8; Prss8; PRSS8_HUMAN; Serine protease 8. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 激酶和磷酸酶 肿瘤细胞生物标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30/33kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PRSS8 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PRSS8 is a member of the trypsin family of serine proteases. It can be found in seminal fluid and is highly expressed in prostate epithelia. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. The carboxyterminal region contains a GPI anchor sequence, which anchors prostasin to the cell surface. Phospholipase activity is thought to liberate prostasin from the cell, and cleavage of the linker region also releases prostasin. PRSS8 has been proposed as a marker for ovarian cancer, where it is up-regulated, a marker for androgen-refractory prostate cancer, where it is down-regulated, and as an inhibitor of invasiveness in breast cancer. Function: Possesses a trypsin-like cleavage specificity. Subunit: Heterodimer of two chains, light and heavy, held by a disulfide bond. Subcellular Location: Prostasin: Cell membrane; Single-pass membrane protein. Prostasin light chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus. Prostasin heavy chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus. Tissue Specificity: Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid. Similarity: Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. Database links: Entrez Gene: 5652 Human Entrez Gene: 76560 Mouse Entrez Gene: 192107 Rat Omim: 600823 Human SwissProt: Q16651 Human SwissProt: Q9ESD1 Mouse SwissProt: Q9ES87 Rat Unigene: 75799 Human Unigene: 5875 Mouse Unigene: 107364 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
PRSS8是丝氨酸蛋白酶的trypsin家族的成员。它可在精液中发现，并在前列腺上皮中高表达。裂解前蛋白以产生由二硫键缔合的轻链和重链。羧基末端区域包含一个GPI锚定序列，锚定前列腺素到细胞表面。磷脂酶活性被认为是从细胞中释放前列腺素，并且连接区的裂解也释放前列腺素。PRSS8已被提议作为卵巢癌的标志物，其上调，是雄激素难治性前列腺癌的标志物，在那里它被下调，并作为乳腺癌侵袭性的抑制剂。