CSRP2,富含半胱氨酸蛋白2抗体

产品编号HZ-12946R
英文名称CSRP2
中文名称富含半胱氨酸蛋白2抗体
别 名CRP 2; CRP2; CSRP2; CSRP2_HUMAN; Cysteine and glycine rich protein 2; Cysteine and glycine-rich protein 2; Cysteine rich protein 2; Cysteine-rich protein 2; LIM domain only 5 smooth muscle; LIM domain only protein 5; LMO 5; LMO-5; LMO5; SmLIM; Smooth muscle cell LIM protein.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 信号转导 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit,
CSRP2,富含半胱氨酸蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量21kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CSRP2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CSRP2,富含半胱氨酸蛋白2抗体PubMedPubMed
产品介绍background:
CRP2 is a 193 amino acid nuclear protein that belongs to the CRP family of LIM domain proteins. Highly expressed in smooth muscle of aorta, CRP2 is thought to have a role in embryonic vascular system development and is downregulated following cell injury or PDGF-B exposure. CRP2 contains two LIM zinc-binding domains and is encoded by a gene that maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.

Function:
Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

Subunit:
Interacts with CSRP2BP. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with GLRX3 (By similarity).

Subcellular Location:
Nucleus.

CSRP2,富含半胱氨酸蛋白2抗体Tissue Specificity:
Highly expressed in the aorta, but not in heart and skeletal muscle.

Similarity:
Contains 2 LIM zinc-binding domains.

Gene ID:
1466

Database links:
Entrez Gene: 1466 Human
Entrez Gene: 13008 Mouse
Entrez Gene: 29317 Rat
Omim: 601871 Human
SwissProt: Q32LE9 Cow
SwissProt: Q16527 Human
SwissProt: P97314 Mouse
SwissProt: Q62908 Rat
Unigene: 530904 Human
Unigene: 2020 Mouse
Unigene: 94754 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.