GDF7,生长分化因子7抗体

产品编号HZ-11461R
英文名称GDF7
中文名称生长分化因子7抗体
别 名bmp12; bone morphogenetic protein 12; GDF-7; Gdf 7; GDF7_HUMAN; growth differentiation factor 7; Growth/differentiation factor 7.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 干细胞 生长因子和激素 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse,
GDF7,生长分化因子7抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量14kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human GDF7 (362-410aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
GDF7,生长分化因子7抗体PubMedPubMed
产品介绍background:
Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1).

Function:
May play an active role in the motor area of the primate neocortex.

Subunit:
Homodimer; disulfide-linked

Subcellular Location:
Secreted.

GDF7,生长分化因子7抗体Similarity:
Belongs to the TGF-beta family.

Database links:
UniProtKB/Swiss-Prot: Q7Z4P5.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.