ABLIM1,肌动蛋白结合蛋白1抗体

产品编号HZ-11449R
英文名称ABLIM1
中文名称肌动蛋白结合蛋白1抗体
别 名ABLIM 1; ABLIM; abLIM-1; ABLIM-L; ABLIM-M; ABLIM-S; ABLIM1; ABLM1_HUMAN; Actin binding double zinc finger protein; Actin binding LIM protein 1; Actin binding LIM protein family member 1; Actin-binding double zinc finger protein; Actin-binding double zinc finger protein; Actin-binding LIM protein 1; Actin-binding LIM protein family member 1; DKFZp781D0148; FLJ14564; KIAA0059; LIM actin binding protein 1; LIMAB 1; LIMAB1; Limatin; RGD1565768; RP11-317F20.1.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 细胞骨架 细胞外基质
抗体来源Rabbit
ABLIM1,肌动蛋白结合蛋白1抗体克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量88kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ABLIM1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ABLIM1,肌动蛋白结合蛋白1抗体PubMedPubMed
产品介绍background:
The C. elegans protein Unc-115 mediates axon guidance by modulating the growth cone Actin cytoskeleton in response to signals received by growth cone receptors. The mammalian homolog of Unc-115 is the Actin-binding LIM protein family member 1 (ABLIM1, also designated Limatin). The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho signaling) dependent activation of serum-response factor (SRF), thereby modulating transcription.

Function:
May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.

Subunit:
Binds F-actin. Interacts with ABRA.

ABLIM1,肌动蛋白结合蛋白1抗体Subcellular Location:
Cytoplasm. Cytoplasm > cytoskeleton. Associated with the cytoskeleton.

Tissue Specificity:
Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers.

Similarity:
Contains 1 HP (headpiece) domain.
Contains 4 LIM zinc-binding domains.

Gene ID:
3983

Database links:
Entrez Gene: 3983 Human
Entrez Gene: 226251 Mouse
Entrez Gene: 307989 Rat
Omim: 602330 Human
SwissProt: O14639 Human
SwissProt: Q8K4G5 Mouse
Unigene: 438236 Human
Unigene: 538331 Human
Unigene: 593868 Human
Unigene: 217161 Mouse
Unigene: 446592 Mouse
Unigene: 40404 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.