FITC标记的热休克因子蛋白5抗体
产品名称： FITC标记的热休克因子蛋白5抗体
英文名称： Anti-HSF5/FITC
产品编号： HZ-16558R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HSF5/FITC Conjugated antibody
FITC标记的热休克因子蛋白5抗体
| 英文名称 | Anti-HSF5/FITC |
| 中文名称 | FITC标记的热休克因子蛋白5抗体 |
| 别 名 | FLJ40311; Heat shock factor protein 5; Heat shock transcription factor 5; Heat shock transcription factor family member 5; HSF 5; HSF5; HSF5_HUMAN; HSTF 5; MGC134827. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HSF5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: HSF5 is a 596 amino acid protein that localizes to the nucleus and is thought to function as a transcription factor. Multiple isoforms of HSF5 exist due to alternative splicing events. The gene encoding HSF5 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Function: May act as a transcriptional factor. Subcellular Location: Nucleus. Similarity: Belongs to the HSF family. Database links: Entrez Gene: 124535 Human SwissProt: Q4G112 Human Unigene: 380061 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
HSF5是一种定位于细胞核的596氨基酸蛋白，被认为是一种转录因子。由于选择性剪接事件存在HSF5的多个异构体。编码HSF5的基因映射到人类17号染色体，其包含超过2.5%的人类基因组并编码超过1200个基因。两个关键的肿瘤抑制基因与17号染色体相关，即p53和BRCA1。肿瘤抑制因子p53通过DNA修复和细胞死亡来调节细胞命运，从而维持细胞遗传完整性。p53表达的异常或丢失与恶性细胞生长和Li Fraumeni综合征有关。与p53一样，BRCA1直接参与DNA修复，尽管它特别被认为是早期发病的乳腺癌和易患卵巢、结肠、前列腺和输卵管癌的遗传决定因素。