FITC标记的ZC3H7A蛋白抗体
产品名称： FITC标记的ZC3H7A蛋白抗体
英文名称： Anti-ZC3H7A/FITC
产品编号： HZ-18467R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ZC3H7A/FITC Conjugated antibody
FITC标记的ZC3H7A蛋白抗体
| 英文名称 | Anti-ZC3H7A/FITC |
| 中文名称 | FITC标记的ZC3H7A蛋白抗体 |
| 别 名 | HSPC055; ZC3H7; ZC3HDC7; zinc finger CCCH type containing 7; zinc finger CCCH type containing 7A; zinc finger CCCH type domain containing 7; zinc finger protein AY163807. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 结合蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 110kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZC3H7A |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ZC3H7A is a 971 amino acid protein that contains a C3H1-type zinc finger domain, three C3H1-type zinc fingers and three TPR repeats. Belonging to the ZC3H12 family, ZC3H7A localizes to the nucleus. Existing as two alternatively spliced isoforms, ZC3H7A is encoded by a gene located on human chromosome 16p13.13. Chromosome 16 makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, though through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene. Subcellular Location: Nuclear Database links: Entrez Gene: 29066 Human SwissProt: Q8IWR0 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ZC3H7A是971氨基酸，含有C3H1型锌指结构域、3个C3H1型锌指和3个TPR重复序列。ZC3H7A属于ZC3H12家族，定位于细胞核。ZC3H7A存在于两个交替剪接的异构体中，由位于人类染色体16p1313上的基因编码。16号染色体构成了人类细胞DNA的近3%，并与多种遗传性疾病相关。GAN基因位于16号染色体上，随着突变，可能导致巨大的轴突神经病变，一种神经系统紊乱，特征是随着生长而增加功能障碍。罕见的Rubinstein-Taybi综合征也与染色体16有关，尽管是通过CREBBP基因编码的关键CREB结合蛋白。Rubinstein Taybi的症状包括精神发育迟滞和肿瘤生长和白细胞肿瘤的易感性。Crohn病是通过NOD2基因与16号染色体相关的胃肠道炎症状态。