FGFR5,成纤维细胞生长因子受体5抗体

产品编号HZ-6049R
英文名称FGFR5
中文名称成纤维细胞生长因子受体5抗体
别 名FGF homologous factor receptor; FGF receptor like protein 1; FGFR 5; FGFR like protein; FGFR5; FGFRL1; FHFR; Fibroblast growth factor receptor 5; Fibroblast growth factor receptor like 1; FGRL1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 生长因子和激素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
FGFR5,成纤维细胞生长因子受体5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量52kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FGFR5/FGFRL1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FGFR5,成纤维细胞生长因子受体5抗体PubMedPubMed
产品介绍background:
FGFRL1 is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between FGFRL1 and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found.

Function:
UniProtKB/Swiss-Prot: Q8N441.1 FASTA Graphics Go to: LOCUS FGRL1_HUMAN 504 aa linear PRI 01-MAY-2013 DEFINITION RecName: Full=Fibroblast growth factor receptor-like 1; Short=FGF receptor-like protein 1; AltName: Full=FGF homologous factor receptor; AltName: Full=FGFR-like protein; AltName: Full=Fibroblast growth factor receptor 5; Short=FGFR-5; Flags: Precursor.

FGFR5,成纤维细胞生长因子受体5抗体Subunit:
Interacts with FGF2 with a low affinity.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.

Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Database links:
UniProtKB/Swiss-Prot: Q8N441.1

FGFR5,成纤维细胞生长因子受体5抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.