中文名称 核转录因子重组兔单克隆抗体 
别    名 sex determining region Y box 1; SOX1_HUMAN; SRY; SOX-1; SRY box containing gene 1; SRY related HMG box gene 1; Transcription factor Sox-1.   
研究领域 发育生物学  神经生物学  干细胞  转录调节因子  表观遗传学   
抗体来源 Rabbit 
克隆类型 Monoclonal 
克 隆 号 23C9 
交叉反应 (predicted: Human, Mouse, Rat, ) 
产品应用 WB=1:500-1000 IP=1:20-100 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. 
分 子 量 39kDa 
细胞定位 细胞核  
性    状 Liquid 
浓    度 1mg/ml 
免 疫 原 Recombinant human SOX1 protein (100-200aa):  
亚    型 IgG 
纯化方法 affinity purified by Protein A 
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 
PubMed PubMed 
产品介绍 Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
 
Function:
Transcriptional activator.
 
Subcellular Location:
Nucleus.
 
Tissue Specificity:
Mainly expressed in the developing central nervous system.
 
Post-translational modifications:
Sumoylation inhibits the transcriptional activity.
 
Similarity:
Contains 1 HMG box DNA-binding domain.
 
SWISS:
O00570
 
Gene ID:
6656
 
Database links:
Entrez Gene: 6656 HumanEntrez Gene: 20664 MouseOmim: 602148 HumanSwissProt: O00570 HumanSwissProt: P53783 MouseUnigene: 202526 HumanUnigene: 39088 Mouse
 
Important Note:
This product as su