PRKAA2 (C-term) Peptide
产品名称： PRKAA2 (C-term) Peptide
英文名称： PRKAA2 (C-term) Peptide
产品编号： P2372
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PRKAA2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PRKAA2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.
Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum MJ, Stuck BJ, Kahn BB.Nature. 2004 Apr 1;428(6982):569-74.
- 2.
- AMP-activated protein kinase plays a role in the control of food intake.
Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D, Small CJ.J Biol Chem. 2004 Mar 26;279(13):12005-8. Epub 2004 Jan 23.
- 3.
- Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.
Browne GJ, Finn SG, Proud CG.J Biol Chem. 2004 Mar 26;279(13):12220-31. Epub 2004 Jan 5.
- Entrez GeneID:
- 5563
- Protein Accession#:
- P54646
- Gene Name:
- PRKAA2
- Gene Alias:
- AMPK,AMPK2,PRKAA
- Gene Description:
- protein kinase, AMP-activated, alpha 2 catalytic subunit
- Omim ID:
- 600497
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq
- Other Designations:
- 5'-AMP-activated protein kinase, catalytic alpha-2 chain,AMP-activated protein kinase alpha 2 catalytic subunit,AMPK-alpha-2 chain,OTTHUMP00000009993