Ecat1,胚胎干细胞相关转录因子1抗体

产品编号HZ-13596R
英文名称Ecat1
中文名称胚胎干细胞相关转录因子1抗体
别 名C6orf221; Chromosome 6 open reading frame 221; ES cell-associated transcript 1 protein; HYDM2; KHD3L_HUMAN; KHDC3-like protein; KHDC3L.
说 明 书0.1ml 0.2ml
研究领域细胞生物 干细胞 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
Ecat1,胚胎干细胞相关转录因子1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量24kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Ecat1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Ecat1,胚胎干细胞相关转录因子1抗体PubMedPubMed
产品介绍background:
ECAT1 (ES cell-associated transcript 1 protein) is a 217 amino acid protein that belongs to the KHDC1 family. The ECAT1 protein contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA. Expression of ECAT1 appears to be maximal in germinal vesicle oocytes, it tails off through metaphase II oocytes and is undetectable following the completion of the oocyte to embryo transition. Specifically expressed in the oocytes, recent studies suggest that ECAT1 may function as a regulator of genomic imprinting in the oocyte. Defects in ECAT1 are the cause of hydatidiform mole recurrent type 2 (HYDM2), a disorder characterized by excessive trophoblast development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy. HYDM2 leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi.

Tissue Specificity:
Expression appears to be maximal in germinal vesicle oocytes, it tails off through metaphase II oocytes and is undetectable following the completion of the oocyte to embryo transition.

Ecat1,胚胎干细胞相关转录因子1抗体DISEASE:
Defects in KHDC3L are the cause of hydatidiform mole recurrent type 2 (HYDM2) [MIM:614293]. A disorder characterized by excessive trophoblast development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi.

Similarity:
Belongs to the KHDC1 family. Contains 1 KH domain.

Gene ID:
154288

Database links:
Entrez Gene: 154288 Human
Omim: 611687 Human
SwissProt: Q587J8 Human
Unigene: 128326 Human

Ecat1,胚胎干细胞相关转录因子1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.