FITC标记的NK细胞抑制性受体3DL1抗体
产品名称： FITC标记的NK细胞抑制性受体3DL1抗体
英文名称： Anti-CD158e/FITC
产品编号： HZ-10758R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CD158e/FITC Conjugated antibody
FITC标记的NK细胞抑制性受体3DL1抗体
| 英文名称 | Anti-CD158e/FITC |
| 中文名称 | FITC标记的NK细胞抑制性受体3DL1抗体 |
| 别 名 | Killer cell immunoglobulin-like receptor 3DL1; AMB11; CD158 antigen-like family member E; CD158E; CD158e antigen; CD158E1; CD158E1/2; CD158E2; CL11; CL2; HLA-BW4-specific inhibitory NK cell receptor; killer cell immunoglobulin like receptor; Killer cell immunoglobulin like receptor three domains , short cytoplasmic tail, 1; Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1; Killer cell immunoglobulin-like receptor 3DL1; KIR; KIR antigen 3DL1; KIR G1; KIR3DS1; Kirl1; Kirl2; Krl1; MGC119726; MGC119728; MGC126589; MGC126591; MHC class I NK cell receptor; Natural killer associated transcript 3; Natural killer cell inhibitory receptor; NK receptor; NK-associated transcript 10; NK-associated transcript 3; NK-associated transcript 3delIg1; NKAT10; NKAT3; NKB1; NKB1B; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clones CL 2/CL 11; KI3L1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD158e |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] Function: Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Similarity: Belongs to the immunoglobulin superfamily. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 3811 Human Omim: 604946 Human SwissProt: P43629 Human Unigene: 645228 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
杀伤细胞免疫球蛋白样受体（KIRs）是由自然杀伤细胞和T细胞亚群表达的跨膜糖蛋白。KIR基因具有多态性和高度同源性，它们位于1Mb白细胞受体复合物（LRC）的19q13.4号染色体上。KIR基因簇的基因含量随单倍型而异，尽管在所有单倍型（KIR3DL3、KIR3DP1、KIR3DL4、KIR3DL2）中都发现了一些“框架”基因。KIR蛋白根据细胞外免疫球蛋白结构域（2D或3D）的数量以及它们具有长（L）或短（S）细胞质结构域进行分类。具有长细胞质结构域的KIR蛋白通过基于免疫酪氨酸的抑制基序(ITIM)转导配体结合的抑制信号，而具有短细胞质结构域的KIR蛋白缺乏ITIM基序，而是与TYRO蛋白酪氨酸激酶结合蛋白t结合。o转导激活信号。几种KIR蛋白的配体是HLA I类分子的亚群，因此，KIR蛋白被认为在调节免疫应答中发挥重要作用。[ RefSeq，JUL 2008 ]