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上海信裕生物科技有限公司
BRIT1抗体

BRIT1抗体

商家询价

产品名称： BRIT1抗体

英文名称： BRIT1Antibody

产品编号： XY11962-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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  • 邮编 : 200612
  • 所在区域 : 上海
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 BRIT1抗体

Applications
In-house applications ELISA, WB, IHC     Application not tested? Please see our Guarantee.
Species specificity Human, Mouse; other species not tested.
Images
Prev1NextView more validation data
  • 11962-1-AP;HeLa cellsHeLa cells were subjected to SDS PAGE followed by western blot with 11962-1-AP(BRIT1 antibody) at dilution of 1:500
  • 11962-1-AP;human prostate cancerImmunohistochemical of paraffin-embedded human prostate cancer using 11962-1-AP(BRIT1 antibody) at dilution of 1:50 (under 10x lens)
Positive WB detected in HeLa cells, L02 cells, MDA-MB-453s cells, mouse ovary tissue
Positive IHC detected in Human prostate cancer tissue, human kidney tissue
Recommended dilution WB : 1:200-1:2000
IHC : 1:20-1:200
 BRIT1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen BRIT1 fusion protein ag2567 Full name Microcephalin 1
Calculated molecular
weight		 93 kDa Observed molecular 
weight		 66 kDa,100 kDa
GenBank accession 
number		 BC030702 Gene ID (NCBI) 79648
Gene symbol MCPH1 Synonyms BRIT1, FLJ12847, MCPH1, MCT, Microcephalin, microcephalin 1
Background BRIT1抗体

Primary microcdphaly refers to the clinical finding of a head circumference less than 3 standard deviations(SD) below the age- and sex-related mean, present at birth. MCPH1, the fisrt gene identified as causative for primary microcephaly, encodes a multifunctional protein that notably is linked to DNA damage checkpoint, DNA repair by homologous recombination and DNA transcription. MCPH1 is associated with premature chromosome condensation in particular. There are two mainly isoforms encoded by MCPH1 gene, isoform1(~100kd) and isoform2(~66kd) BRIT1抗体

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