FITC标记的肿瘤抑制相关蛋白PHEMX抗体
产品名称： FITC标记的肿瘤抑制相关蛋白PHEMX抗体
英文名称： Anti-ART1/FITC
产品编号： HZ-12531R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ART1/FITC Conjugated antibody
FITC标记的肿瘤抑制相关蛋白PHEMX抗体
| 英文名称 | Anti-ART1/FITC |
| 中文名称 | FITC标记的肿瘤抑制相关蛋白PHEMX抗体 |
| 别 名 | ART 1; ART1; FLJ17158; FLJ97586; MGC22455; Pan hematopoietic expression; PHEMX; PHMX; tetraspanin 32; Tetraspanin; tetraspanin32; TSPAN32; TSSC6; Tumor suppressing STF cDNA 6; Tumor suppressing subchromosomal transferable fragment cDNA 6; Tumor suppressing subtransferable candidate 6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 35kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PHEMX/ART1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Phemx is a member of the tetraspanin (TM4SF) family of proteins that may be involved in transmembrane signal transduction, regulation of cell proliferation, differentiation and motility. Phemx is a multi-pass membrane protein containing intracellular N- and C-terminal domains, four transmembrane domains and two extracellular loops. It is ubiquitously expressed from early embryogenesis through adulthood. Phemx exhibits predominant expression in hematopoietic tissues suggesting a role in hematopoietic-cell function. In association with the Integrin αIIb/Integrin β3 complex, Phemx functions to stabilize arterial thrombi in platelets and regulate “outside-in” signaling. This interaction may be important in the process of wound healing. The gene encoding Phemx is located in an important tumor-suppressor gene region that has been associated with Beckwith-Wiedemann syndrome as well as a variety of cancers. Function: PHEMX belongs to the conserved tetraspanin family of integral membrane proteins, which are thought to form multiprotein networks in the cell membrane in association with multiple protein partners. Tetraspanins have functional roles in cell motility, membrane fusion, proliferation, and adaptive immunity. This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. PHEMX may play a role in malignancies and disease that involve this region as well as hematopoietic cell function. There are 5 isoforms produced by alternative splicing. Subcellular Location: Membrane; Multi-pass membrane protein Tissue Specificity: Expressed ubiquitously at low levels. High levels of expression are confined to hematopoietic tissues including peripheral blood leukocytes, thymus and spleen. Similarity: Belongs to the tetraspanin (TM4SF) family. Database links: Entrez Gene: 417 Human Omim: 601625 Human SwissProt: P52961 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Phemx是川芎嗪（TM4SF）家族的成员，该家族可能参与跨膜信号转导、细胞增殖、分化和运动调节。Phemx是含有细胞内N、C端结构域、四个跨膜结构域和两个细胞外环的多通道膜蛋白。它是通过早期胚胎发育普遍表达的成年期。PHEMX在造血组织中的表达主要表现在造血细胞功能中。与整合素αIIb/整合素β3复合物相关，Phemx具有稳定血小板中的动脉血栓和调节“内外”信号的功能。在伤口愈合过程中，这种相互作用可能是重要的。Phemx基因位于与Beckwith-Wiedemann综合征相关的一个重要抑癌基因区域。