EPCR,内皮细胞活化蛋白受体/CD201抗体

产品编号HZ-9506R
英文名称EPCR
中文名称内皮细胞活化蛋白受体/CD201抗体
别 名Activated protein C receptor; APC receptor; APCR; CCCA; CCD41; CD201 antigen; centrocyclin; Endothelial cell protein C receptor; MGC23024; PROCR; EPCR_HUMAN; CD201.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 免疫学 干细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
EPCR,内皮细胞活化蛋白受体/CD201抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EPCR/CD201
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EPCR,内皮细胞活化蛋白受体/CD201抗体PubMedPubMed
产品介绍background:
EPCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. It is an N glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. It is expressed strongly in the endothelial cells of arteries and veins in heart and lung. It is overexpressed in several human non-Pgp multidrug resistant (MDR) tumor cell lines. Whether and how anti-coagulant and anti-inflammatory functions of EPCR facilitate oncogenesis and/or drug resistance is unclear.

Function:
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

Post-translational modifications:
N-glycosylated.
A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.

EPCR,内皮细胞活化蛋白受体/CD201抗体Database links:
Entrez Gene: 10544 Human
Omim: 600646 Human
SwissProt: Q9UNN8 Human
Unigene: 647450 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.