XAF1 polyclonal antibody
产品名称： XAF1 polyclonal antibody
英文名称： XAF1 polyclonal antibody
产品编号： PAB13116
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of XAF1.
- Immunogen:
- A synthetic peptide corresponding to C-terminus of human XAF1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Specificity:
- A 32 KDa band can be detected.
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis.
Leaman DW, Chawla-Sarkar M, Vyas K, Reheman M, Tamai K, Toji S, Borden EC.J Biol Chem. 2002 Aug 9;277(32):28504-11. Epub 2002 May 23.
- 2.
- Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines.
Fong WG, Liston P, Rajcan-Separovic E, St Jean M, Craig C, Korneluk RG.Genomics. 2000 Nov 15;70(1):113-22.
- 3.
- X-linked IAP is a direct inhibitor of cell-death proteases.
Deveraux QL, Takahashi R, Salvesen GS, Reed JC.Nature. 1997 Jul 17;388(6639):300-4.
- Entrez GeneID:
- 54739
- Protein Accession#:
- CAA68030
- Gene Name:
- XAF1
- Gene Alias:
- BIRC4BP,HSXIAPAF1,XIAPAF1
- Gene Description:
- XIAP associated factor 1
- Omim ID:
- 606717
- Gene Ontology:
- Hyperlink
- Gene Summary:
- X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001 [PubMed 11175744]).[supplied by OMIM
- Other Designations:
- BIRC4 binding protein