FITC标记的细胞色素cP450 CYP26A1抗体
产品名称： FITC标记的细胞色素cP450 CYP26A1抗体
英文名称： Anti-CYP26A1/FITC
产品编号： HZ-12928R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CYP26A1/FITC Conjugated antibody
FITC标记的细胞色素cP450 CYP26A1抗体
| 英文名称 | Anti-CYP26A1/FITC |
| 中文名称 | FITC标记的细胞色素cP450 CYP26A1抗体 |
| 别 名 | CP26; CP26A_HUMAN; CYP26; CYP26A 1; cyp26a1; Cytochrome P450 26A1; Cytochrome P450 family 26 subfamily A polypeptide 1; Cytochrome P450 retinoic acid-inactivating 1; cytochrome P450, family 26, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIA, polypeptide 1; Cytochrome P450RAI; hP450RAI; OTTHUMP00000020102; OTTHUMP00000020103; P450; P450 retinoic acid inactivating 1; P450RAI; P450RAI1; Retinoic acid 4 hydroxylase; Retinoic acid 4-hydroxylase; Retinoic acid metabolizing cytochrome; Retinoic acid-metabolizing cytochrome. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CYP26A1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP26A1 is a major retinoic acid catabolic enzyme. CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor ∫2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, imperforate anus, agenesis of the caudal portions of the digestive and urogenital tracts, and malformed lumbosacral skeletal elements. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryos. Function: Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. Subcellular Location: Endoplasmic reticulum membrane. Microsome membrane. Tissue Specificity: Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain. Similarity: Belongs to the cytochrome P450 family. Database links: UniProtKB/Swiss-Prot: O43174.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
细胞色素P450蛋白（CYPs）是单加氧酶，催化许多涉及药物代谢和合成胆固醇、类固醇和其他脂质的反应。根据它们的序列相似性，将P450酶分为亚科。CYP26A1是一种主要的视黄酸分解代谢酶。CYP26A1在保护尾芽组织免受不适暴露于视黄酸中起重要作用。CYP26A1转录受核视黄酸受体2的表观遗传调控。编码CYP26A1的基因突变与尾侧发育不全和脊柱裂、肛门闭锁、消化道和泌尿生殖道尾侧部分的发育不全、以及畸形的腰骶骨元素有关。CYP26A1在腺瘤性息肉病大肠杆菌腺瘤、人FAP腺瘤、人散发性结肠癌中上调，在