FITC标记的神经丛蛋白A1抗体
产品名称： FITC标记的神经丛蛋白A1抗体
英文名称： Anti-Plexin A1/FITC
产品编号： HZ-2692R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Plexin A1/FITC Conjugated antibody
FITC标记的神经丛蛋白A1抗体
| 英文名称 | Anti-Plexin A1/FITC |
| 中文名称 | FITC标记的神经丛蛋白A1抗体 |
| 别 名 | NOV; NOV/plexin A1 protein; NOVP; Plexin1; PlexinA1; PLXN1; PLXNA1; PLXNA1; protein; Semaphorin receptor NOV; PLXA1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 免疫学 发育生物学 神经生物学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 206kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Plexin A1 (926-974aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contain a semaphorin domain, multiple glycine rich motifs, and MET related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin mediated activation of Plexin A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin A1. The expression of Plexin A1, along with the co receptor Neuropilin 1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin A1 and Neuropilin 1, may have significant roles in axon regeneration after neuronal injury. Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Subunit: Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Subcellular Location: Cell membrane (Probable); Single-pass type I membrane protein. Tissue Specificity: Detected in fetal brain, lung, liver and kidney. Similarity: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain. Database links: Entrez Gene: 5361 Human Entrez Gene: 18844 Mouse NCBI: NP_115618 Human Omim: 601055 Human SwissProt: Q9UIW2 Human SwissProt: P70206 Mouse Unigene: 432329 Human Unigene: 549421 Human Unigene: 3789 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Plexins是一种单途径、具有多向潜在功能的跨膜蛋白，为Sema-phorins（神经信号蛋白）家族的受体,PlexinA1蛋白主要定位于细胞质和细胞膜，Semaphorins的很多重要的生理作用均是通过Plexins信号传导来发挥作用的。PlexinA1在神经系统形成、心血管生成、胚胎发生和免疫反应等方面发挥重要作用 |
丛蛋白是一种大的整合膜蛋白，与神经素复合物形成信号素共受体。丛蛋白的胞外区域包含信号素域、多甘氨酸富集基序和MET相关序列。细胞质区包含性/丛蛋白结构域和推测的酪氨酸磷酸化位点，介导激活后的信号转导。在Pulin A1中的这一区域结合Rho GTP酶、RND1和RhoD。RND1的募集被牵涉到细胞骨架崩解发生在信号素介导的丛蛋白A1激活之后，而RhoD可以通过与丛蛋白A1的细胞质区域相互作用来阻止这种塌陷活动。在中枢神经系统损伤后，丛粘连蛋白A1和共受体神经素1的表达上调。这些神经元的轴突不能在损伤部位交叉含信号素3A的区域。因此，信号素3a及其共受体、丛蛋白A1和神经素1可能在神经元损伤后轴突再生中发挥重要作用。