FITC标记的RecQ解旋酶样蛋白5抗体
产品名称： FITC标记的RecQ解旋酶样蛋白5抗体
英文名称： Anti-RECQL5/FITC
产品编号： HZ-11231R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-RECQL5/FITC Conjugated antibody
FITC标记的RecQ解旋酶样蛋白5抗体
| 产品编号 | bs-11231R-FITC |
| 英文名称 | Anti-RECQL5/FITC |
| 中文名称 | FITC标记的RecQ解旋酶样蛋白5抗体 |
| 别 名 | ATP-dependent DNA helicase Q5; DNA helicase, RecQ like type 5; DNA helicase, RECQ-like, type 5; RecQ helicase protein-like 5 beta; RecQ protein-like 5; RecQ protein-like 5, isoform CRA_b; RecQ5; Recq5b; Recql5b; RECQ5_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 染色质和核信号 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 109kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RECQL5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: RecQ helicases are implicated in DNA recombination and repair helicases and are critical in genome maintenance. RecQL5 is one of five known RecQ homologues in humans, and defects in three of these (BLM, WRN and RecQ4)are associated with autosomal recessive disorders that involve genomic instability and a predisposition to cancer. The exact role of ReqL5 is unclear. It has been shown in mouse embryonic stem (ES) cells that mutations in the Recql5 genes result in a significant increase in the frequency of sister chromatid exchange (SCE), whereas deleting Recql5 lead to an even higher frequency of SCE. There are three different RecQL5 isoforms - alpha, beta and gamma, produced by alternative splicing. Function: May have an important role in DNA metabolism. Subunit: Interacts with TOP3A and TOP3B. Subcellular Location: Cytoplasmic and Nuclear, depending on the isoform. Tissue Specificity: Ubiquitous Similarity: Belongs to the helicase family. RecQ subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Database links: Entrez Gene: 483317 Dog Entrez Gene: 9400 Human Entrez Gene: 287834 Rat Omim: 603781 Human SwissProt: O94762 Human Unigene: 632229 Human Unigene: 198916 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ReqQ解旋酶与DNA重组和修复解旋酶有关，在基因组维持中至关重要。ReqL5是人类已知的五种Req同系物之一，其中三种（BLM、WRN和Req4）中的缺陷与常染色体隐性遗传疾病有关，常涉及基因组不稳定性和癌症易感性。ReqL5的确切作用尚不清楚。在小鼠胚胎干细胞中已经发现，在ReqL5基因中的突变导致姐妹染色单体交换（SCE）频率的显著增加，而删除ReqL5导致SCE的更高频率。有三种不同的ReqL5亚型-α，β和γ，由选择性剪接产生。