FITC标记的白介素-1受体拮抗剂抗体
产品名称： FITC标记的白介素-1受体拮抗剂抗体
英文名称： Anti-IL-1RA/FITC
产品编号： HZ-2216R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-IL-1RA/FITC Conjugated antibody
FITC标记的白介素-1受体拮抗剂抗体
| 英文名称 | Anti-IL-1RA/FITC |
| 中文名称 | FITC标记的白介素-1受体拮抗剂抗体 |
| 别 名 | Interleukin-1 receptor antagonist; ICIL 1RA; IL1 inhibitor; ICIL1RA; IL1F3; IL1RN; IRAP; IL1RA_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-1RA |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: IL1RA is a member of the Interleukin 1 cytokine family. This protein inhibits the activities of Interleukin 1, alpha (IL1A) and Interleukin 1, beta (IL1B), and modulates a variety of Interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. Function: Inhibits the activity of interleukin-1 by binding to eceptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. Subcellular Location: Isoform 1: Secreted. Isoform 2, 3, 4: Cytoplasm. Tissue Specificity: The intracellular form of IL1RN is predominantly expressed in epithelial cells. DISEASE: Microvascular complications of diabetes 4 (MVCD4) [MIM:612628]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Interleukin 1 receptor antagonist deficiency (DIRA) [MIM:612852]: A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells. Note=The disease is caused by mutations affecting the gene represented in this entry. Database links: Entrez Gene: 3557 Human Entrez Gene: 16181 Mouse Entrez Gene: 60582 Rat Omim: 147679 Human SwissProt: P18510 Human SwissProt: P25085 Mouse SwissProt: P25086 Rat Unigene: 81134 Human Unigene: 882 Mouse Unigene: 162640 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IL-1受体拮抗剂(IL-1ra)是IL-1强有力的内生拮抗剂，通过与白细胞介素-1的Ⅰ型和Ⅱ型受体结合，特异性地阻断白细胞介素-1的生物学作用。白介素1受体拮抗剂(IL-1Ra)是体内天然的一种对IL-1有拮抗作用的细胞因子 |
IL1RA是白细胞介素1细胞因子家族的成员。该蛋白抑制白细胞介素1，α（IL1A）和白细胞介素1，β（IL1B）的活性，并调节多种白细胞介素1相关的免疫和炎症反应。这个基因和其他五个密切相关的细胞因子基因在2号染色体上形成一个大约400kb的基因簇。据报道，该基因的多态性与骨质疏松性骨折和胃癌的风险增加有关。报道了四种编码不同亚型的剪接转录变体。