PDX1 polyclonal antibody
产品名称： PDX1 polyclonal antibody
英文名称： PDX1 polyclonal antibody
产品编号： PAB2102
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PDX1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PDX1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Pancreatic duodenal homeobox-1 (PDX1) functions as a tumor suppressor in gastric cancer.
Ma J, Chen M, Wang J, Xia HH, Zhu S, Liang Y, Gu Q, Qiao L, Dai Y, Zou B, Li Z, Zhang Y, Lan H, Wong BC.Carcinogenesis. 2008 Jul;29(7):1327-33. Epub 2008 May 13.
- 2.
- Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription.
Watada H, Kajimoto Y, Kaneto H, Matsuoka T, Fujitani Y, Miyazaki J, Yamasaki Y.Biochem Biophys Res Commun. 1996 Dec 24;229(3):746-51.
- Entrez GeneID:
- 3651
- Protein Accession#:
- NP_000200;P52945
- Gene Name:
- PDX1
- Gene Alias:
- GSF,IDX-1,IPF1,IUF1,MODY4,PDX-1,STF-1
- Gene Description:
- pancreatic and duodenal homeobox 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq
- Other Designations:
- OTTHUMP00000018174,glucose-sensitive factor,insulin promoter factor 1, homeodomain transcription factor,insulin upstream factor 1,pancreatic-duodenal homeobox factor 1,somatostatin transcription factor 1
- Related Disease
- Atherosclerosis
- Cardiovascular Diseases
- Cerebral Infarction
- Diabetes Mellitus
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetes, Gestational
- Edema
- Genetic Predisposition to Disease
- Glucose Intolerance
- Hypercholesterolemia
- Hypertension
- Intracranial Arteriosclerosis
- Kidney Failure, Chronic
- Metabolic Syndrome X
- Myocardial Infarction
- Obesity
- Renal Insufficiency, Chronic
- Werner syndrome