C8orf4,8号染色体开放阅读框4抗体

产品编号HZ-15289R
英文名称C8orf4
中文名称8号染色体开放阅读框4抗体
别 名C8orf4; CH004_HUMAN; Chromosome 8 open reading frame 4; Human thyroid cancer 1; MGC22806; TC-1; TC1; Thyroid cancer protein 1; Uncharacterized protein C8orf4.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 染色质和核信号 信号转导 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
C8orf4,8号染色体开放阅读框4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量12kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human C8orf4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
C8orf4,8号染色体开放阅读框4抗体PubMedPubMed
产品介绍background:
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]

Function:
May decrease apoptosis.

Subunit:
Monomer.

Tissue Specificity:
Ubiquitous. Expressed in thyroid papillary carcinoma.

Database links:
Entrez Gene: 56892 Human
Omim: 607702 Human
SwissProt: Q9NR00 Human
Unigene: 591849 Human

C8orf4,8号染色体开放阅读框4抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.