FITC标记的内质网蛋白ERp19抗体
产品名称： FITC标记的内质网蛋白ERp19抗体
英文名称： Anti-ERp19/FITC
产品编号： HZ-13105R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ERp19/FITC Conjugated antibody
FITC标记的内质网蛋白ERp19抗体
| 英文名称 | Anti-ERp19/FITC |
| 中文名称 | FITC标记的内质网蛋白ERp19抗体 |
| 别 名 | AG1; AGR1; anterior gradient homolog 1; endoplasmic reticulum protein ERp19; endoplasmic reticulum resident protein 18; endoplasmic reticulum resident protein 19; endoplasmic reticulum thioredoxin superfamily member, 18 kDa; ER protein 18; ER protein 19; ERP 18; ERP16; ERP19; hAG 1; hAG1; hTLP19; PDIA16; protein disulfide isomerase family A, member 16; thioredoxin domain containing 12 (endoplasmic reticulum; Thioredoxin domain-containing protein 12; thioredoxin like protein p19; TLP19; TXNDC12; TXD12_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转运蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ERp19 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Endoplasmic reticulum proteins (ERps) are widely expressed proteins and localize to the ER. ERp19, ERp29, ERp46, ERp57 and ERp72 may act as proteases, protein disulfide isomerases, thiol-disulfide oxidases, phospholipases or a combination of these. ERp19, also designated thioredoxin domain-containing protein 12 (TXNDC12), and ERp46, also designated thioredoxin domain containing 5 (TXNDC5), belong to the thioredoxin superfamily and contain a thioredoxin fold with a consensus active-site sequence (CxxC). Both ERp19 and ERp46 are widely expressed ER luminal proteins that are most abundant in the liver and are enriched in purified liver ER vesicles. ERp19 shows significant protein thiol-disulfide oxidase activity in vitro, which is dependent on the presence of both active-site cysteines. Function: ERp19 belongs to the thioredoxin superfamily. Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors. Possesses significant protein thiol-disulfide oxidase activity. Subcellular Location: Endoplasmic reticulum. Tissue Specificity: Widely expressed. Similarity: Contains 1 thioredoxin domain. Database links: UniProtKB/Swiss-Prot: O95881.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Endoplasmic reticulum proteins（Erp）是广泛表达的蛋白，定位于ER。ERp19、ERp29、ERp46、ERp57和ERp72可作为蛋白酶、蛋白二硫化物异构酶、巯基二硫化物氧化酶、磷脂酶或其组合。ERp19，也称为硫氧还蛋白结构域包含蛋白12（TXNDC12），ERp46，也称为硫氧还蛋白结构域包含5（TXNDC5），属于硫氧还蛋白超家族，并包含具有共同活性位点序列（CxxC）的硫氧还蛋白折叠。ERp19和ERp46都是广泛表达的ER腔蛋白，在肝脏中含量最丰富，并且富含纯化的肝脏ER小泡。ERp19在体外显示出显著的蛋白巯基二硫化物氧化酶活性，这取决于两个活性位点半胱氨酸的存在。