FITC标记的神经内分泌调节肽VGF抗体
产品名称： FITC标记的神经内分泌调节肽VGF抗体
英文名称： Anti-VGF/FITC
产品编号： HZ-10332R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-VGF/FITC Conjugated antibody
FITC标记的神经内分泌调节肽VGF抗体
| 英文名称 | Anti-VGF/FITC |
| 中文名称 | FITC标记的神经内分泌调节肽VGF抗体 |
| 别 名 | NERP-2; NERP2; Nerve growth factor inducible; Neuroendocrine regulatory peptide-2; Neurosecretory protein VGF; VGF; VGF_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 发育生物学 神经生物学 信号转导 生长因子和激素 内分泌病 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Danio rerio |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 4.2/65kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NERP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. Nerve growth factor (NGF) is a peptide that plays a key role in the differentiation and survival of neurons in the peripheral nervous system (PNS) and the central nervous system (CNS). VGF is a peptide synthesized and secreted by neurons and is upregulated by NGF in the PC12 cell line. VGF is widely expressed in both the PNS and CNS, but is especially abundant in the adult hypothalamus. VGF plays an essential role in how the brain regulates energy expenditure and body weight. Its expression is rapidly induced by injury, the circadian clock, and neuronal activity. Function: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system. NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release. Subcellular Location: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus. Tissue Specificity: Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. Post-translational modifications: Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure. Database links: Entrez Gene: 7425 Human Entrez Gene: 381677 Mouse Entrez Gene: 29461 Rat Omim: 602186 Human SwissProt: O15240 Human SwissProt: P20156 Rat Unigene: 587325 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因在神经内分泌细胞亚群中特异表达，并被神经生长因子上调。该基因的结构结构与大鼠基因相似，翻译区和非翻译区与大鼠基因序列高度相似。该编码分泌蛋白与分泌素/嗜铬粒蛋白家族也有相似之处，但其确切功能尚不清楚。
神经生长因子（NGF）是周围神经系统（PNS）和中枢神经系统（CNS）神经元分化和存活过程中起关键作用的肽。VGF是由神经元合成和分泌的肽，在PC12细胞系中由NGF上调。VGF在PNS和CNS中广泛表达，但在成年下丘脑中尤为丰富。VGF在大脑如何调节能量消耗和体重方面起着至关重要的作用。它的表达是由损伤、昼夜节律和神经元活动引起的。