FITC标记的同源盒转录因子LMX1A抗体-抗体-抗体-生物在线
上海沪震实业有限公司
FITC标记的同源盒转录因子LMX1A抗体

FITC标记的同源盒转录因子LMX1A抗体

商家询价

产品名称： FITC标记的同源盒转录因子LMX1A抗体

英文名称： Anti-LMX1A/FITC

产品编号： HZ-12386R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-LMX1A/FITC Conjugated antibody

FITC标记的同源盒转录因子LMX1A抗体

 

英文名称 Anti-LMX1A/FITC
中文名称 FITC标记的同源盒转录因子LMX1A抗体
别    名 HGNC:6653; LIM homeobox protein 1.1; LIM homeobox transcription factor 1 alpha; LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 1.1; LIM/homeobox protein LMX1A; LMX 1; LMX 1.1; LMX 1A; LMX-1.1; LMX1; LMX1.1; LMX1A; LMX1A_HUMAN; MGC87616.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 发育生物学  神经生物学  干细胞  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LMX1A
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
LMX1A belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1A functions in the nucleus as a transcriptional activator to the insulin gene promoter. In the developing embryo, LMX1A is expressed along the neuraxis and leads to the development of the roof plate of the vertebrae. Two isoforms of LMX1A exist due to alternative splicing. Isoform 1 represents the full length protein and is expressed in many tissues including fetal brain, but is absent in heart, liver, spleen and testis. The second isoform, designated LMX1A-4AB, lacks amino acids 1-249 and is expressed in testis.

Function:
Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.

Subcellular Location:
Nucleus.

Tissue Specificity:
Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis. Relatively highly expressed in fetal brain. Isoform LMX1A-4B is expressed in testis.

Similarity:
Contains 1 homeobox DNA-binding domain.
Contains 2 LIM zinc-binding domains.

Database links:
UniProtKB/Swiss-Prot: Q8TE12.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

LMX1A属于LIM同源结构域家族。这个家族的成员在发展过程中对模式的形成是很重要的。LMX1A在细胞核中作为胰岛素基因启动子的转录激活剂发挥作用。在发育中的胚胎中，LMX1A沿神经轴表达，并导致椎体顶板的发育。LMX1A的两种异构体由于选择性剪接而存在。异型1代表全长蛋白，在包括胎脑在内的许多组织中表达，但在心脏、肝脏、脾脏和睾丸中缺失。第二亚型，命名为LMX1A-4AB，缺乏氨基酸1-249，并在睾丸中表达。