TNK2 (C-term) Peptide
产品名称： TNK2 (C-term) Peptide
英文名称： TNK2 (C-term) Peptide
产品编号： P2741
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TNK2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human TNK2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:10-50)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck.
Yokoyama N, Miller WT.J Biol Chem. 2003 Nov 28;278(48):47713-23. Epub 2003 Sep 22.
- 2.
- A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42.
Manser E, Leung T, Salihuddin H, Tan L, Lim L.Nature. 1993 May 27;363(6427):364-7.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of TNK2 polyclonal antibody (Cat # PAB3416) in CEM cell line lysates (35 ug/lane). TNK2 (arrow) was detected using the purified polyclonal antibody.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with TNK2 polyclonal antibody (Cat # PAB3416) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 10188
- Protein Accession#:
- Q07912
- Gene Name:
- TNK2
- Gene Alias:
- ACK,ACK1,FLJ44758,FLJ45547,p21cdc42Hs
- Gene Description:
- tyrosine kinase, non-receptor, 2
- Omim ID:
- 606994
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq
- Other Designations:
- activated Cdc42-associated kinase 1,activated p21cdc42Hs kinase