Ribonuclease 3/ECP,嗜酸性粒细胞阳离子蛋白抗体

产品编号HZ-8615R
英文名称Ribonuclease 3/ECP
中文名称嗜酸性粒细胞阳离子蛋白抗体
别 名eosinophil cationic protein; EAR; Ear11; Ear4; EAR5; ECP; LOC192264; MGC143624; mR3; mR5; R1; R14; R15; R17; R5; R7; Ribonuclease 3; Rnase17; Rnase2; RNASE3; RNS3; ECP_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 通道蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
Ribonuclease 3/ECP,嗜酸性粒细胞阳离子蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量16kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Ribonuclease 3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Ribonuclease 3/ECP,嗜酸性粒细胞阳离子蛋白抗体PubMedPubMed
产品介绍background:
ECP is a 160 amino acid potent cytotoxic secretory protein that belongs to the pancreatic ribonuclease family. ECP localizes to the granule matrix of the eosinophil and is involved in the immune response system. ECP is a cytotoxin, neurotoxin and helminthotoxin that is secreted by activated human eosinophils. ECP exhibits anti-parasitic, antibacterial and ribonucleolytic activities. It has been suggested that ECP induces the neurotoxic effect known as the Gordon phenomenon, a syndrome manifested by ataxia, muscular rigidity, paralysis, and tremor that may lead to death. ECP is considered a marker of eosinophilic inflammation and high levels have been found in cases of active asthma and other allergic diseases

Function:
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity.

Subunit:

Subcellular Location:
Cytoplasmic granule. Matrix of eosinophil's large specific granule.

Post-translational modifications:

Similarity:
Belongs to the pancreatic ribonuclease family.

Gene ID:
6037

Ribonuclease 3/ECP,嗜酸性粒细胞阳离子蛋白抗体Database links:
Entrez Gene: 6037 Human
Entrez Gene: 53876 Mouse
Entrez Gene: 100361866 Rat
Entrez Gene: 192264 Rat
Omim: 131398 Human
SwissProt: P12724 Human
SwissProt: O35290 Mouse
SwissProt: P70709 Rat
Unigene: 73839 Human
Unigene: 327386 Mouse
Unigene: 10626 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.