FGF20,成纤维细胞生长因子20抗体

产品编号HZ-5772R
英文名称FGF20
中文名称成纤维细胞生长因子20抗体
别 名FGF-20; Fgf20; FGF20_HUMAN; FGFK; Fibroblast Growth Factor 20.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 信号转导 生长因子和激素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow,
FGF20,成纤维细胞生长因子20抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FGF20.
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FGF20,成纤维细胞生长因子20抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009].

Function:
Neurotrophic factor that regulates central nervous development and function.

Subunit:
Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

Subcellular Location:
Secreted.

FGF20,成纤维细胞生长因子20抗体Tissue Specificity:
Predominantly expressed in the cerebellum.

Similarity:
Belongs to the heparin-binding growth factors family.

Gene ID:
26281

Database links:
Entrez Gene: 26281 Human
Entrez Gene: 80857 Mouse
Entrez Gene: 66017 Rat
Omim: 605558 Human
SwissProt: Q9NP95 Human
SwissProt: Q9ESL9 Mouse
SwissProt: Q9EST9 Rat
Unigene: 199905 Human
Unigene: 425526 Mouse
Unigene: 64492 Rat

FGF20,成纤维细胞生长因子20抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.