FITC标记的细胞色素B5还原酶2抗体
产品名称： FITC标记的细胞色素B5还原酶2抗体
英文名称： Anti-CYB5R2/FITC
产品编号： HZ-14131R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CYB5R2/FITC Conjugated antibody
FITC标记的细胞色素B5还原酶2抗体
| 英文名称 | Anti-CYB5R2/FITC |
| 中文名称 | FITC标记的细胞色素B5还原酶2抗体 |
| 别 名 | b5R.2; Cyb5r2; Cytochrome b5 reductase 2; Cytochrome b5 reductase b5R.2; NADH cytochrome b5 reductase 2; NADH-cytochrome b5 reductase 2; NB5R2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CYB5R2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: NADH-cytochrome b5 reductases participate in a variety of physiological processes including biosynthesis of cholesterol, methemoglobin reduction of erythrocytes, elongation of fatty acids and metabolism of drugs. CYB5R2 (cytochrome b5 reductase 2), also known as B5R.2, is a 276 amino acid protein that contains one FAD-binding FR-type domain and belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. Existing as two alternatively spliced isoforms, CYB5R2 reduces 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt and lucigenin in spermatozoa, which results in NADH-dependent lucigenin chemiluminescence. CYB5R2 binds FAD as a cofactor and is encoded by a gene located on human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11. Function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1). Tissue Specificity: Restricted expression. Similarity: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. Contains 1 FAD-binding FR-type domain. Database links: Entrez Gene: 51700 Human Entrez Gene: 320635 Mouse Entrez Gene: 365345 Rat Omim: 608342 Human SwissProt: Q6BCY4 Human SwissProt: Q3KNK3 Mouse SwissProt: Q6AY12 Rat Unigene: 414362 Human Unigene: 132828 Mouse Unigene: 16198 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NADH-细胞色素b5还原酶参与多种生理过程，包括胆固醇的生物合成、红细胞高铁血红蛋白的还原、脂肪酸的伸长和药物的代谢。CYB5R2（细胞色素b5还原酶2），又称B5R.2，是一种276个氨基酸的蛋白质，含有一个FAD结合FR型结构域，属于黄酮蛋白吡啶核苷酸细胞色素还原酶家族。CYB5R2作为两种选择性剪接异构体存在，在精子中还原2-[4-碘苯基]-3-[4-**苯基]-5-[2，4-二磺基苯基]-2H四唑单钠盐和荧光素，导致NADH依赖性荧光素化学发光。CYB5R2结合FAD作为辅因子，并且由位于人类染色体11上的基因编码，该基因包含1400多个基因，并且包含近4％的人类基因组。Jervell和Lange-Nielsen综合征、Jac.n综合征和Smith-Lemli-Opitz综合征与映射到11号染色体的基因缺陷有关。