FITC标记的MXI1蛋白抗体
产品名称： FITC标记的MXI1蛋白抗体
英文名称： Anti-MXI1/FITC
产品编号： HZ-19115R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MXI1/FITC Conjugated antibody
FITC标记的MXI1蛋白抗体
| 英文名称 | Anti-MXI1/FITC |
| 中文名称 | FITC标记的MXI1蛋白抗体 |
| 别 名 | bHLHc11; Class C basic helix-loop-helix protein 11; MAD 2; MAD2; MAX dimerization protein 2; MAX interacting protein 1; Max interactor 1; Max related transcription factor; MAX-interacting protein 1; MGC43220; MXD 2; MXD2; MXI 1; MXI; mxi1; MXI1 protein; MXI1_HUMAN; Protein MXI1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 21kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MXI1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008] Function: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX. Subcellular Location: Nucleus. Tissue Specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle. DISEASE: Defects in MXI1 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Database links: Entrez Gene: 4601 Human Entrez Gene: 17859 Mouse Entrez Gene: 25701 Rat Omim: 600020 Human SwissProt: P50539 Human SwissProt: P50540 Mouse SwissProt: O09015 Rat Unigene: 501023 Human Unigene: 602078 Human Unigene: 676603 Human Unigene: 2154 Mouse Unigene: 37510 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产生致癌转录因子的c-myc基因在正常细胞中的表达受到严格调节，但在人类癌症中经常被解除调节。该基因编码的蛋白是一种被认为负调控MYC功能的转录抑制因子，因此是一种潜在的肿瘤抑制因子。该蛋白通过与MAX竞争，抑制MYC的转录活性，MAX是另一种与MYC结合的基础螺旋-环-螺旋蛋白，是MYC功能所必需的。在前列腺癌患者中经常发现这种基因的缺陷。已经描述了三种编码不同亚型的剪接转录本。可能存在另外的可选剪接转录本，但这些转录本的产物尚未通过实验验证。[ RefSeq，JUL 2008 ]