FITC标记的分泌素受体抗体
产品名称： FITC标记的分泌素受体抗体
英文名称： Anti-Secretin receptor/FITC
产品编号： HZ--0089R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Secretin receptor/FITC Conjugated antibody
FITC标记的分泌素受体抗体
| 英文名称 | Anti-Secretin receptor/FITC |
| 中文名称 | FITC标记的分泌素受体抗体 |
| 别 名 | 6530402O03Rik, MGC102218, MGC93381, SCTR, SR; Secretin receptor; SCT-R; SCTR_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 信号转导 生长因子和激素 细胞膜受体 内分泌病 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 46kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from the middle of human Secretin receptor |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The receptor for secretin is a class 2 (or class B) G protein coupled receptor that signals through Gs to stimulate cAMP production. Along with its traditional role in the pancreas, studies in secretin-deficient mice have shown miscommunication between the CA3 Schaffer collateral and CA1 pyramidal neurons, causing a deficiency in synaptic transmission. This miscommunication of CA1 dendrites is found in Autism, Rett Syndrome, and most forms of mental retardation, suggesting secretin could be a potential target for treatment of these disorders. Function: This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 2 family. Database links: Entrez Gene: 6344 Human Omim: 182098 Human SwissProt: P47872 Human Unigene: 42091 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
分泌素的受体是2（或B）类G蛋白偶联受体，通过G信号刺激cAMP的产生。除了在胰腺中的传统作用外，在分泌素缺乏的小鼠中进行的研究已经表明，CA3 Schaffer侧枝和CA1锥体神经元之间的错误通信，导致突触传递的缺乏。这种CA1树突的沟通失调在孤独症、Rett综合症和大多数形式的智力低下中都有发现，提示分泌素可能是治疗这些疾病的潜在靶点。