FITC标记的脂肪瘤相关蛋白抗体
产品名称： FITC标记的脂肪瘤相关蛋白抗体
英文名称： Anti-LIM protein/LPP/FITC
产品编号： HZ-3861R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-LIM protein/LPP/FITC Conjugated antibody
FITC标记的脂肪瘤相关蛋白抗体
| 英文名称 | Anti-LIM protein/LPP/FITC |
| 中文名称 | FITC标记的脂肪瘤相关蛋白抗体 |
| 别 名 | DKFZp779O0231; FLJ30652; FLJ41512; LIM domain containing preferred translocation partner in lipoma; LIM domain-containing preferred translocation partner in lipoma; LIM protein; Lipoma preferred partner; Lipoma-preferred partner; lpp; LPP_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 细胞粘附分子 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 80kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LIM protein C-terminus |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: LPP (LIM containing lipoma preferred partner), is a scaffolding protein which contains three LIM domains at its carboxy terminus, preceded by a proline rich pre LIM region containing a number of protein interaction domains. LPP localizes to sites of cell adhesion, such as focal adhesions and cell-cell contacts and may be involved in cell-cell adhesion and cell motility. LPP also shuttles through the nucleus and may function as a transcriptional co-activator. The human LPP gene maps to chromosomal location 3q28, and preferentially translocates to the HMGIC gene in a subclass of human benign mesenchymal tumors known as lipomas. Alternate splicing results in multiple transcript variants. Function: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. Subcellular Location: Nucleus. Cytoplasm. Cell junction. Cell membrane. Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and MLL. Tissue Specificity: Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes. DISEASE: Note=A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas. Note=A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas. Note=A chromosomal aberration involving LPP is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma. Note=A chromosomal aberration involving LPP is associated with acute monoblastic leukemia. Translocation t(3;11)(q28;q23) with MLL is associated with acute monoblastic leukemia. Similarity: Belongs to the zyxin/ajuba family. Contains 3 LIM zinc-binding domains. Database links: Entrez Gene: 4026 Human Entrez Gene: 210126 Mouse Omim: 600700 Human SwissProt: Q93052 Human SwissProt: Q8BFW7 Mouse Unigene: 5724 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
LPP（LIM含有脂肪瘤的首选伙伴），是一种支架蛋白，其羧基端含有三个LIM结构域，之前含有富含蛋白质相互作用结构域的富含脯氨酸的前LIM区域。LPP定位于细胞粘附位点，如局灶性粘连和细胞-细胞接触，并可能参与细胞-细胞粘附和细胞运动。LPP也穿梭于细胞核，并可作为转录共激活剂发挥作用。人类LPP基因定位于染色体位置3q28，并优先转移到HMGIC基因，在人类良性间叶肿瘤的一个亚类中被称为脂肪瘤。交替剪接导致多个转录变体。